Decaris instructions for use. Decaris: instructions for use, analogues and reviews, prices in Russian pharmacies. Instructions for use and dosing regimen

Content

For the treatment of worms that live in the intestines and blood, doctors prescribe Decaris - the instructions for using the drug contain information that it can be used to strengthen the immune system. The medication contains a potent substance, so you need to follow the exact dosage that does not exceed the recommended one to prevent side effects.

Decaris tablets

Compound

The drug Decaris is available in the form of tablets with different concentrations of the active substance. Their composition and description are shown in the table:

50 mg levamisole is rapidly absorbed from gastrointestinal tract, reaches a maximum concentration within 1.5-2 hours from the moment of administration. In the liver, the substance is actively metabolized, glucuronide and hydroxylevamisole serve as metabolites. The drug is excreted from the body in 6-12 hours, excreted by the intestines (0.2%) and kidneys (no more than 5%).

Indications for use

infection with helminths from the genus Ascaris lumbrocoides, Necator and Americanus Ancylostoma duodenale;
ascariasis, enterobiasis (roundworms, pinworms, roundworms);
trichuriasis, ankylostomiasis (whipworm, hookworms);
necatorosis, toxoplasmosis (necator, toxoplasma);
strongyloidiasis, trichostrongylosis (intestinal acne, nematodes).

As an immunomodulator

The instructions indicate that Decaris has an immunomodulatory effect, but today this drug is little used in this vein due to not the mildest action. Previously, the drug was used for herpes simplex and herpes zoster, chronic hepatitis B, rheumatoid arthritis, recurrent stomatitis, frequent acute respiratory diseases in children, Crohn's and Reiter's diseases. Decaris can be used for malignant tumors in periods after surgery, chemotherapy or radiation therapy.

For prevention

How to take adults

Tablets from worms Decaris, according to the instructions, are used once. In the treatment of helminthiases, adults are prescribed 150 mg, children 3-6 years old - 25-50 mg, 6-10 years old - 50-75 mg, 10-14 years old - 75-100 mg once. The drug is taken after meals, in the evening, washed down with a small amount of water. While taking the medication, there is no need to take laxatives or follow a special diet. You can repeat the use of tablets in 1-2 weeks.

For the treatment of toxoplasmosis, a three-day course is carried out on a tablet once a day. The course must be repeated 2-3 times with a break of seven days. A similar therapy regimen is used for immunomodulation with intervals between doses of 14 days. According to the instructions, after two courses, the use of the medication is reduced to a weekly one tablet. The duration of treatment is determined by the result of immunological tests.

For kids

According to the instructions, Decaris is contraindicated for children under the age of three years and at a concentration of 150 mg. The child is supposed to take 50 mg tablets after a doctor's prescription. One 50 mg tablet is designed for 10 kg of body weight. With a body weight of 30 kg, it is supposed to take three tablets once or one adult dose. Without weight, the dosage is: 3-6 years - 25-50 mg, 6-10 years - 50-75 mg, 10-14 years - 75-100 mg.

special instructions

According to reviews, taking Decaris as an anthelmintic drug can depress nervous system. During the use of the tablet, short-term mild dizziness may occur, which will affect the concentration of attention and the speed of psychomotor reactions. Therefore, against the background of therapy with the drug, it is better to refuse to control mechanisms and cars.

As part of the antihelminthic drug 150 mg, lactose is present, so patients with galactose and lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome should not be used. 150 mg tablets also contain sucrose, which should be taken into account when used in patients diabetes first or second type.

Decaris during pregnancy

Doctors do not recommend the use of Decaris during pregnancy, because it has embryotoxic properties - it can lead to problems in the development of the fetus and even death. The purpose of the drug is possible for health reasons, if the benefit to the mother exceeds the risk to the fetus. According to the instructions, levamisole passes into breast milk, so you should stop breastfeeding while taking it.

Decaris and alcohol

It is forbidden to combine the substance levamisole with alcoholic beverages or drink alcohol at the same time as Decaris. This threatens with the development of disulfiram-like phenomena: the heart begins to beat more often, skin blush, blood pressure decreases, there comes an aversion to alcohol and nausea. A minimum of 24 hours should elapse between taking the tablets and ethanol.

drug interaction

During treatment, the drug should be combined with caution with drugs that affect the process of hematopoiesis. Instructions for use warns: the combination of the drug with coumarin-like anticoagulants increases the prothrombin time, so dose adjustment is required. Decaris is able to increase the level of Phenytoin in the blood and increase the effect of Phenytoin. The combination of the drug with lipophilic drugs (Tetrachloromethane, Tetrachlorethylene, Ether, Chloroform, Chenopodium Oil) is prohibited due to increased toxicity of the drug.

Side effects

Side effects of the anthelmintic drug indicated in the instructions:

insomnia, headache;
dizziness, rapid heartbeat;
convulsions, nausea, vomiting;
abdominal pain, diarrhea;
uterine bleeding, impaired renal function;
encephalopathy (reversible, eliminated by the use of glucocorticosteroid therapy);
allergic reactions: skin rash, itching, burning;
large doses can lead to leukopenia, tremor, agranulocytosis.

Overdose

When using a dose of levamisole over 600 mg, overdose symptoms appear: nausea, vomiting, drowsiness. A person feels dizzy, convulsions, diarrhea, confusion of consciousness develop. With the constant use of large doses of the drug, the balance is disturbed immune system, the bone marrow is affected, the number of leukocytes in the blood decreases. Treatment consists of gastric lavage or induction of vomiting, monitoring of vital signs. Symptomatic therapy is carried out, with anticholinesterase signs, Atropine is administered.

Contraindications

The instructions for use of Decaris say that 150 mg tablets are contraindicated in children and adolescents under 14 years of age, 50 mg tablets - up to three years. With caution, a remedy is prescribed for renal or hepatic insufficiency, inhibition of bone marrow hematopoiesis, pregnancy. Contraindications for the use of the drug are agranulocytosis against the background of the use of drugs, even in history, lactation.

Terms of sale and storage

Decaris can only be bought with a prescription from a doctor, stored at a temperature of 15-30 degrees away from children for five years.

Analogues

According to the active substance of the composition, the drug is unique and has no analogues. Substitutes for a drug with the same therapeutic effect are the following drugs:

Vermox;
Medamin;
Wormin;
Pirantel;
Telmox;
Nemozol;
Helmintox;
mebendazole;
Vero-mebendazole.;
Biltricide;
Pirvinium pamoa;
pumpkin seeds;;
tansy flowers.

Decaris Price

You can buy Decaris in pharmacies or through Internet sites at a cost whose level is affected by the trade margin and the concentration of the active substance in the medicine. Approximate prices for the drug in pharmacies in Moscow and St. Petersburg.

Levamisole hydrochloride, corn starch, sodium saccharinate, talc, povidone, apricot flavor, magnesium stearate, yellow dye.

Release form

Tablets - flat, round, light orange 50 and 150 mg in a blister pack No. 1 and 2 in a carton box.

pharmachologic effect

Anthelmintic .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Wikipedia defines Decaris as anthelmintic , which has an immunomodulatory effect. The drug depolarizes the muscle membranes of helminths, inhibits the enzymatic activity of fumarate reductase and succinate dehydrogenase, and suppresses bioenergetic processes. Paralyzed nematodes are removed from the body by intestinal peristalsis within a day after taking the drug.

The immunomodulatory effect of the drug is manifested by increased production of antibodies to antigens and T-cell response, activation of T-lymphocytes, increased function of macrophages, monocytes and neutrophils (phagocytosis, chemotaxis and adhesion).

Pharmacokinetics

When taken orally, the drug is rapidly absorbed from the gastrointestinal tract. Smakh in the blood after taking the drug is achieved in 1.5-2 hours. The metabolism of levamisole occurs in the liver, its metabolites are glucuronide and hydroxy-levamisole. The half-life is 3-6 hours. Excreted as metabolites in urine and feces.

Indications for use

helminth infection ( hookworm , , necatorosis , trichostrongylosis , trichuriasis , strongyloidiasis , ).

Contraindications

high sensitivity to the drug;
history of caused medicines;
age up to 3 years;
period of pregnancy and lactation.

Take with caution oppression of bone marrow hematopoiesis , hepatic and kidney failure .

Side effects

Insomnia, headache, dizziness, convulsions, palpitations, , dyspeptic disorders, skin rash, leukopenia , agranulocytosis , .

Tablets Decaris, instructions for use (Method and dosage)

For adults, take orally with meals at the following dosage:

At toxoplasmosis : once at a time 150 mg per day for three days. If necessary, the course of treatment can be repeated with interruptions of one 1 week.
At helminthiases : once, at bedtime at a dose of 150 mg for adults and at the rate of 2.5 mg / kg for children. If necessary, the course can be repeated in 1-2 weeks.

Instructions for the use of Decaris indicate the need for a study of peripheral blood before starting treatment, and during the period of treatment - to control the number of leukocytes. While taking the drug and after, for one day, it is strictly forbidden to drink alcohol.

Overdose

When taking a large dose of the drug (more than 600 mg), signs of intoxication may appear in the form of nausea, vomiting, headache, dizziness, drowsiness, diarrhea, convulsions and confusion.

Interaction

Decaris should not be taken with ethanol , lipophilic compounds (carbon tetrachloride , butter chenopodium , tetrachlorethylene , chloroform ) and drugs that cause leukopenia.

The drug enhances the effect indirect anticoagulants and .

Terms of sale

On prescription.

Storage conditions

At a temperature of 15-25°C.

Shelf life

60 months.

Decaris for children

Decaris for children, given the significant number of possible side effects in the treatment of helminthiasis, it can be taken only after consulting a doctor. Tablets for children are available in a dose of 50 mg of levamisole.

How to take the drug for children? One tablet (50 mg) is designed for 10 kg of a child's weight. The instructions for the drug contain the calculation of the dosage for children. Approximate dosages for children from 3 to 6 years old are 25-50 mg; from 6 to 10 -50-75 mg; from 10 to 14 years - 75-100 mg. However, the calculation of the dosage by the weight of the child is more accurate and reduces the likelihood of side effects.

Decaris to improve immunity

It is practically not used to increase immunity in children. There are many modern highly effective and relatively safe immunomodulators that, if necessary, the doctor will prescribe to your child. Reviews about taking Decaris in children are in most cases positive. According to them, side effects occur less frequently in children than in adults. This is probably due to the fact that parents, giving Decaris from worms to a child, strictly observe the dosage of the drug prescribed by the doctor. The reviews note the good antihelminthic effect of Decaris, and the convenience of a single dose.

Decaris: instructions for use and reviews

Decaris is an anthelmintic drug.

Release form and composition

Decaris is produced in the form of tablets: flat, round, chamfered; 50 mg: light orange in color, with a “+” label on one side, with a slight apricot smell (2 pcs in blister packs, 1 pack in a carton box); 150 mg: almost white, with the inscription "DECARIS 150" on one side (1 pc. in blister packs, 1 pack in a carton box).

1 tablet contains active substance: levamisole - 50 or 150 mg (levamisole hydrochloride - 59 or 177 mg (respectively)).

Auxiliary components that are part of the tablets:

50 mg: sodium saccharin, corn starch, apricot flavor, povidone, magnesium stearate, talc, sunset yellow (E110);
150 mg: povidone, cornstarch, lactose monohydrate, talc, sucrose, magnesium stearate.

Also, the drug has an immunomodulatory effect, which is expressed in increased production of antibodies to antigens and T-cell response, increased activity of T-lymphocytes, improved functions of neutrophils, monocytes and macrophages (adhesion, chemotaxis, phagocytosis).

Pharmacokinetics

When oral administration of levamisole at a dose of 50 mg, it is absorbed from the gastrointestinal tract very quickly. The maximum plasma level is recorded approximately 1.5-2 hours after taking the drug. Levamisole is extensively metabolized in the liver with the formation of the main metabolites - n-hydroxy-levamisole and its glucuronide.

The half-life of the substance from the body is 3-6 hours. It is excreted unchanged through the kidneys (less than 5% of the administered dose) and with faeces (less than 0.2% of the administered dose).

Indications for use

According to the instructions, Decaris is prescribed for infection with helminths Ascaris lumbrocoides, Ancylostoma duodenale and Necator Americanus.

Contraindications

Agranulocytosis associated with the use of drugs (history);
Age up to 3 years;
lactation period (breastfeeding);
Hypersensitivity to the components of the drug.

For children, Decaris tablets at a dose of 150 mg are not prescribed.

The drug should be taken with caution in cases of bone marrow suppression and in patients with hepatic and / or renal insufficiency.

Instructions for use Decaris: method and dosage

Decaris should be taken orally, after meals in the evening, with a small amount of water. There is no need for a special diet or laxatives.

The drug is taken once. Adults are usually prescribed 1 tablet of 150 mg. Children should take the drug based on age and weight:

3-6 years (from 10 to 20 kg) - 0.5-1 tablet of 50 mg (25-50 mg);
6-10 years (from 20 to 30 kg) - 1-1.5 tablets of 50 mg (50-75 mg);
10-14 years (from 30 to 40 kg) - 1.5-2 tablets of 50 mg (75-100 mg).

If necessary, after 1-2 weeks, the reception of Decaris can be repeated.

Side effects

During therapy, side effects such as palpitations, headache, dizziness, insomnia, convulsions, dyspeptic symptoms (vomiting, nausea, diarrhea, abdominal pain) may develop.

There are also reports of the development, 2-5 weeks after taking the drug, of disorders from the central nervous system in the form of encephalopathy and allergic reactions manifesting as a skin rash.

In most cases, these phenomena are reversible. The prognosis is improved by early use of glucocorticosteroids.

The relationship of these side effects with taking Decaris is not entirely convincing, but when taking the drug in large doses or with prolonged treatment, leukopenia, tremor, and agranulocytosis may develop.

Overdose

When taking a large dose of Decaris (more than 600 mg), symptoms of intoxication such as dizziness, headache, clouded consciousness, drowsiness, seizures, nausea, vomiting, and diarrhea may occur.

If the overdose was accidental, and the drug was taken relatively recently, it is recommended to do a gastric lavage. It is necessary to conduct regular monitoring of the vital functions of the body and prescribe symptomatic therapy. If signs of anticholinesterase action occur, atropine may be administered.

special instructions

Do not drink alcohol 24 hours after taking the drug.

Sufficient evidence that levamisole, used as an anthelmintic agent, depresses the nervous system, is not available.

When taking Decaris, mild, transient dizziness may occur, which must be taken into account when driving vehicles and working with complex mechanisms.

Use during pregnancy and lactation

The appointment of Decaris during pregnancy is permissible only in cases where the intended benefit of therapy for the mother is more significant than the potential risks to the fetus.

If it is necessary to treat the drug during lactation, it is advisable to stop breastfeeding.

drug interaction

At the same time, it is impossible to use Decaris with lipophilic preparations (tetrachloromethane, chenopodium oil, tetrachlorethylene, ether or chloroform), since this combination may increase its toxicity.

With the simultaneous administration of levamisole with alcoholic beverages, disulfiram-like phenomena may be observed.

Care must be taken when using Decaris with drugs that affect hematopoiesis.

Prothrombin time may increase while taking levamisole with coumarin-like anticoagulants, and therefore it is necessary to adjust the dose of oral anticoagulant.

Decaris can increase the level of phenytoin in the blood, therefore, with the simultaneous use of these drugs, it should be monitored.

Analogues

Analogues of Decaris are: Levamisole, Vermox, Wormin, Biltricid, Helmintox, Nemozol, Pirantel, Piperazine, Medamin, Mebendazole, Telmox, Pumpkin seeds, Tansy flowers.

Terms and conditions of storage

Keep out of the reach of children at a temperature of 15-30 °C.

Shelf life - 5 years.

Decaris is an anthelmintic drug used to prevent and treat helminthiases - infection of the body with roundworms that cause diseases such as:

ascariasis,
hookworm,
necatorosis,
strongyloidiasis,
trichostrongylosis,
trichuriasis,

Unlike Troychatki Evalar, which is a dietary supplement, Decaris is a drug.

The description of Decaris indicates that it should be prescribed and taken with caution. Decaris contraindicated pregnant women, nursing mothers, children under 14 years of age, patients with a history of hypersensitivity to the drug, with diseases associated with certain changes in the composition of the blood. Decaris is used with caution in cases of impaired functioning of the kidneys, liver, hematopoietic system, including in the acute stage of leukemia. Also, it is necessary to take into account the interaction of Decaris with other substances and drugs, for example, it is completely incompatible with alcohol.

The former popularity of Decaris still provides him with a steady demand. Gradually losing its position in the treatment of people, it remains very popular in veterinary medicine. Years of experience this drug and patient reviews confirm that it is an effective remedy against roundworms. However, one cannot but pay attention to the imperfections of Decaris: toxicity, a strong effect on important systems organism, incompatibility with many drugs.