Gramicidin C - instructions for use, release forms, analogues and prices. Gramicidin C - official * instructions for use Gramicidin tablets instructions for use

Gramicidin C is a polypeptide antibiotic produced by the spore bacterium Bacillus brevis var.G.-B. Gramicidin C, due to the formation of a network of channels in the lipid structures of the membrane, increases the permeability of the cell membrane of the microorganism for inorganic cations, which leads to osmotic instability of the cell. Gramicidin C acts bacteriostatically (including meningococci, Streptococcus pneumoniae, pathogens of anaerobic infections, gonococci), and in high concentrations bactericidal (on Staphylococcus spp. And Streptococcus spp.). Gramicidin C is used only locally, since when administered parenterally, phlebitis and generalized hemolysis develop. Pharmacokinetic data are not available due to low systemic absorption.

Indications

Buccal tablets: infectious and inflammatory pathology of the pharynx and oral cavity: acute tonsillitis, pharyngitis, tonsillitis, gingivitis, periodontal disease, stomatitis.
Solution: bedsores, purulent wounds, ulcers, osteomyelitis, skin burns, joint injuries, phlegmon, furuncle, empyema, carbuncle, pyoderma; inflammatory pathology of the throat and ear.
Paste: wounds, burns, local contraception.

Method of application of gramicidin C and dose

Gramicidin C is used topically. Buccal tablets slowly dissolve in the mouth. Solutions are used for irrigation of tampons and dressings, washing, lubricating the skin. The paste is applied in a thin layer under a gauze napkin (the bandage is changed after 2-4 days) on the affected surface or injected into the vagina with a special syringe (for contraception). The duration of therapy, dose, frequency of use, route of administration - depend on the indications, degree and nature of the lesion.

Contraindications for use

Hypersensitivity, period breastfeeding, dermatosis (for external use).

Application restrictions

Pregnancy.

Use during pregnancy and lactation

Pregnant women should consult their doctor before using Gramicidin C. The use of gramicidin C is possible if the expected benefit to the mother outweighs the potential risk to the fetus. During therapy with gramicidin C, breastfeeding should be discontinued.

Side effects of gramicidin C

Contact dermatitis, allergic reactions.

Interaction of gramicidin C with other substances

Gramicidin C enhances the effects of other antimicrobials.

Overdose

An overdose of gramicidin C can cause digestive disorders due to superinfection and changes in the bacterial flora: nausea, vomiting, diarrhea. It is necessary to stop the drug and consult a doctor.

Trade names of drugs with the active ingredient gramicidin C

Combined drugs:
Gramicidin C + Dexamethasone + Framycetin: Sofradex;
Gramicidin C + Lidocaine hydrochloride: Grammidin® with anesthetic;
Gramicidin C + Oxybuprocaine + Cetylpyridinium chloride: Grammidin® with neo anesthetic;
Gramicidin C + Cetylpyridinium chloride: Grammidin® children, Grammidin® neo.

One tablet contains 0.0015 g of gramicidin C. Additional components: food flavor, lactose, sodium saccharinate, sucrose, calcium stearate.

1 ml of the concentrate contains 20 mg of gramicidin C. 1 ml of 95% ethyl alcohol is added as an auxiliary substance.

Medicinal properties

The effect of the drug is to increase the throughput properties of the intercellular septum of the microbe, and its subsequent death. Thus, the activity of microbes is reduced, the processes of inflammation slow down. Reduced by anesthetic pain in the throat, making it easier to swallow. Prolonged melting of the tablet leads to the destruction of microbes in the mouth and on the mucous membrane of the throat. "Gramicidin" is not absorbed in the stomach and intestines, so there are very few negative effects.

Indications for use

"Gramicidin C", tablets are prescribed to patients with infectious and inflammatory diseases of the mucous membrane of the throat and oral cavity:

1. Gingivitis
2. Tonsillitis
3. Angina
4. Stomatitis
5. periodontal disease
6. Pharyngitis

A concentrated solution with anesthetic, diluted in:

Fat or water, can be applied as lotions, dressings, used as a washing agent for the following diseases:

• Furuncles
• Articular injuries
• Osteomyelitis
• festering wounds
• burns
• Phlegmon
• carbuncle
• empyema
• ulcers
• Pressure sores

Alcohol solution, used for pyoderma

Water is used for:

• gingivitis
• Periodontitis
• Tonsillitis
• Periodontitis
• glossy
• stomatitis
• Pharyngitis
• angina
• Removal of teeth.

The average price is from 140 to 180 rubles.

Tablets "Gramicidin C"

Gramicidin is sold in 1.5mg tablets, which is a single dose for children under the age of six and eliminates the need to split an adult tablet in half. Thus, children over the age of six and adults can take 2 of these tablets to reach the prescribed dosage. They are round, flat, with a risk in the middle, white or slightly yellowish. They taste sweet, with a slight bitter aftertaste.

Packed tablets:

1. 10 pcs in contour blisters with or without cells
2. 20 pcs in plastic or dark glass bottles.

Each vial or 2 blisters with tablets are placed in a cardboard box along with instructions. This placement is justified by the number of tablets that make up the minimum treatment course - 20 pcs. It will be enough for adults to purchase 2-3 packs, depending on the destination.

Mode of application

Take after meals, put on the cheek and dissolve, but do not chew. If there are two tablets, they are taken alternately. It is desirable that the total reception time takes no more than half an hour. When the tablets are completely dissolved, you need to refrain from food and drink for about one to two hours.

Children 4-6 years old are prescribed one tablet at a time. At the age of 6 to 12 years - one or two tablets (but not more than 7 per day). Adults are prescribed two tablets. You need to take the medicine four times a day for five to six days. Gramicidin can be used for more than six days only with the direction of a doctor.

The average price is from 160 to 200 rubles.

Solution "Gramicidin C"

It is also produced in the form of a concentrate, from which a solution can subsequently be obtained, as a semi-finished product or a solution ready for use. All three anesthetic options contain 2% alcohol. They are yellow or light yellow in color.

The solution is poured into 5 or 2 ml jars. Jars with a solution and a concentrate are placed one in each package, with a semi-finished product - three.

Mode of application

The contents of the jar are diluted in water in a ratio of 1 to 150. If a solution is prepared on fat, one part of the concentrate and 25 parts of fish oil, lanolin or castor oil are taken. For dilution in alcohol, take one part of the concentrate and 100 parts of 70% ethanol.

A solution is used for washing, irrigating dressings and tampons (2 to 3 times a day).

Contraindications

You can not use:

• Children under 4 years old
• In the presence of individual intolerance to the components that are part of the anesthetic
• If there is a dermatosis (concerns solutions for external use).

During pregnancy and breastfeeding

During pregnancy, take only as directed by a specialist. If a woman is breastfeeding, the medicine should not be taken.

Precautionary measures

In diabetes mellitus, the dosage should be carefully calculated, taking into account the presence of 0.05 XE in one tablet. "Gramicidin", dissolved in water, is good for three days after preparation. Intravenous administration solution is prohibited - there is a risk of hemolysis and phlebitis.

Interaction with other drugs

When taken together with drugs that have antibacterial effect, the effect of the latter is enhanced.

Side effects

The anesthetic property of the drug can cause temporary numbness of the tongue. There is a possibility of an allergic reaction to the components of the anesthetic.

Overdose

If the indicated dosage is exceeded, diarrhea, nausea and vomiting may occur. In such a situation, it is better to stop taking the medicine and consult a specialist.

Terms and conditions of storage

"Gramicidin" should be stored in a dry, dark place where access to children is closed, at an air temperature not exceeding 25 ° C. Valid for three years from the date of manufacture.

Analogues

Valenta Pharmaceutics OJSC, Russia
Price from 232 to 250 rubles.

The main active ingredients of Grammidin are: gramicidin C dihydrochloride (0.003 g), anesthetic oxybuprocaine (0.002 g) and cetylpyridinium chloride monohydrate (0.001 g). Tablets "Grammidin" have the form of round white discs, convex on both sides. They are sweet, with a pleasant pronounced mint flavor.

pros

• Among the components of Grammidin is an antiseptic that neutralizes bacteria that Gramicidin does not act on, and an anesthetic that reduces pain in the throat
• The taste of Grammidin is better

Minuses

• Not allowed during pregnancy
• The cost is higher than Gramicidin.

Diseases of the upper respiratory tract(in particular, the throat) and dental ailments are not always perceived by patients as a serious problem.

Meanwhile, the focus of inflammation in the mouth and throat can result in serious complications, up to systemic lesion articular, cardiac or muscle tissues.

To avoid such problems, at the first sign of a sore throat or the appearance of foci of inflammation in the oral cavity, it is recommended to start treatment with local antimicrobials, which include Gramicidin C tablets.

Gramicidin is a fairly well-known brand of medicines that belongs to the group of bacteriostatics that are active against streptococcal, meningococcal, gonococcal infections and other types of anaerobic bacteria.

Gramicidin C acts on the permeability of bacterial cell membranes, causing instability of osmosis in it, due to which the colonies of pathogenic microflora die.

The line of preparations includes a paste for external use, lozenges, powders for the preparation of oily or aqueous solutions. For the treatment of ENT diseases, a drug in the form of tablets for resorption in the mouth is more suitable. With this method of application, the medicine acts where it is really needed, that is, on the mucous membrane of the throat and in the oral cavity.

Considering that the dissolution of one tablet takes about 20 minutes, it becomes clear that this time will be enough for the active compound of the drug to begin to act on the maximum number of bacteria.

Despite the fact that the dosage form is intended for topical use, that is, it does not enter the systemic circulation, Gramicidin C tablets can change some indicators of body functions. Not always such influences can have a positive ending. That is why you need to strictly follow the instructions for using the medicine.

Gramicidin C is available in the form of tablets for buccal administration, that is, for resorption in the mouth. The medicine looks like white flat-cylindrical tablets with a risk on one of the surfaces. The tablets do not have a specific smell, but they taste sweet and sour.

Gramicidin C lozenges contain one active compound - gramicidin in the amount of 1.5 mg per tablet, as well as additional components: calcium stearate, lactose, sucrose, soluble saccharin and food flavoring. It is they who give them a peculiar sweetish aftertaste and stabilize the active compound, preventing it from disintegrating under the influence of external factors.

Tablets are packed in contour packs of 10 pieces each or in polymer jars of 20 pieces each. One medicine package contains 2 contour packs or 1 polymer jar.

They also include instructions for using the tablets.

Indications for use

The manufacturer recommends using Gramicidin C tablets when inflammatory diseases mucous membrane of the mouth and throat caused by anaerobic microorganisms:

• angina;
• inflammatory gum disease.

Also, the drug can be used in case of injury to the oral mucosa or after dental procedures.

Mode of application

• children from 4 to 6 years old are allowed to use one tablet at a time;
• children from 6 to 12 years old can use 1 or 2 tablets per dose, but not more than 7 pieces per day;
• children over 12 years of age and adults are recommended to dissolve 2 tablets four times a day.

If you need to use 2 tablets according to the instructions, the interval between them should be at least 20 minutes. A prerequisite - after using the tablets, it is not recommended to drink or eat for an hour. This will increase the time interval during which the antibiotic will actively resist the pathogenic microflora.

The duration of treatment with Gramicidin C is 5 to 6 days. If you need to continue therapy, you must first obtain permission from the doctor.

drug interaction

Gramicidin may enhance the effect of topical antimicrobials.

Side effects

When using buccal tablets, you may experience side effects as allergic reactions, expressed in hyperemia of the mucosa, sore throat, dry mouth. In addition, patients with lactose intolerance may develop signs of indigestion or food allergies.

Contraindications

The drug is contraindicated for use by patients who have a history of intolerance to individual components of the dosage form. Gramicidin C should be used with extreme caution in persons diagnosed with diabetes mellitus or lactose intolerance.

Do not use the medicine for pregnant women, especially in the first trimester, as well as during breastfeeding.

Women who are pregnant are not recommended to use Gramicidin C lozenges, the same applies to nursing mothers.

Terms and conditions of storage

Gramicidin C tablets should be stored in places where they will not be accessible to children and pets. The temperature in the room should not fall below +10 degrees Celsius, and rise above +25 degrees Celsius.

Store the tablets in their original packaging, and do not expose them to direct sunlight.

Compliance with these standards guarantees the preservation medicinal properties drug for 2 years. After this time, you need to dispose of the medicine without releasing it from the original packaging.

Price

The cost of Gramicidin C tablets cannot be called high, however, given that a package of 20 tablets lasts an average of 3-5 days, a full course of treatment may require the purchase of two packages of the drug.

In Russian pharmacies the cost of 20 tablets is an average of 200 rubles.

In Ukrainian pharmacies the cost of a package of 20 tablets is an average of 143 hryvnia.

Analogues

Complete analogues, that is, synonyms of the drug Gramicidin C are drugs of the same line, which, in addition to gramicidin, include anesthetics and other additional components. In addition, tablets can be replaced with drugs that contain other names of antibiotics:

• Anti Angin and others.

Due to the fact that the listed drugs have a different composition, it is not recommended to independently replace Gramicidin C with them.

Instructions for use:

Gramicidin C is an antibiotic drug for local and external use.

Release form and composition

Gramicidin C is produced in the following dosage forms:

• Lozenges: flat-cylindrical with a chamfer, white with a yellowish tinge or white, on one side of the risk, on the other - marking "R", or without it (20 pieces in polymer cans, 1 can in a carton box; 10 pieces in blister packs, 2 packs in a carton box);
• Concentrate for the preparation of a solution for local and external use alcohol 2%: a solution from yellow to light yellow (5 or 10 ml in vials, 1 vial in a cardboard box).

The composition of 1 tablet includes:

• Active substance: gramicidin C - 1.5 mg;
• Auxiliary components: milk sugar (lactose) - 441.69 mg; calcium stearate - 6 mg; food flavor - 1.98 mg; sugar (sucrose) - 148.2 mg; sodium saccharin (soluble saccharin) - 0.63 mg.

The composition of 1 ml of concentrate for the preparation of a solution for local and external use includes:

• Active substance: gramicidin C - 20 mg;
• Auxiliary components: ethanol (ethyl alcohol 95%) - up to 1 ml.

Indications for use

Gramicidin C in the form of buccal tablets is used in the treatment of infectious and inflammatory diseases of the throat and oral cavity, including pharyngitis, acute tonsillitis (tonsillitis), gingivitis, periodontal disease, stomatitis.

The drug in the form of a concentrate for the preparation of a solution for external and topical use is used in the treatment of the following diseases:

• Fat and water solution: burns, bedsores, purulent wounds, ulcers, osteomyelitis, empyema, joint trauma, carbuncle, furuncle, phlegmon (in the form of washings, tampons and irrigation of dressings);
• Alcohol solution: pyoderma;
• Aqueous solution: infectious and inflammatory diseases of the mouth and throat, including periodontal disease, tonsillitis, tonsillitis, pharyngitis, periodontitis, stomatitis, gingivitis, glossitis, etc. Also, an aqueous solution is used in the removal and treatment of teeth (as an auxiliary drug).

As part of combination therapy, Gramicidin C is prescribed for the treatment of blepharitis, infected eyelid eczema, meibomitis (barley).

Contraindications

• lactation period;
• Hypersensitivity to the components of the drug.

Pregnant women should use the drug with caution.

Lozenges are contraindicated in children under 4 years of age; children 4-12 years of age should take the drug with caution.

Additionally, contraindications to the use of Gramicidin C in the form of a concentrate for the preparation of a solution for topical and external use are dermatoses.

Method of application and dosage

Gramicidin C in the form of lozenges should be taken sublingually (slowly dissolving in the mouth, without chewing), after meals. For 1-2 hours after using the drug, you should refrain from taking drinks and food.

The drug is taken 4 times a day. A single dose is determined by age:

• Children 4-6 years old - 1 tablet;
• Children 6-12 years old - 1-2 tablets (no more than 7 tablets per day);
• Children from 12 years old and adults - 2 tablets each (for 20-30 minutes one after the other).

The duration of the therapeutic course is 5-6 days. According to the doctor's prescription, the drug can be used for a longer time.

The Gramicidin C solution prepared from the concentrate is used externally and topically.

To prepare one rinse, the concentrate should be diluted in 100 ml drinking water. A single dose of the drug for adults is 10 ml, for children - 5 ml. Procedures should be carried out 2-3 times a day.

To prepare an aqueous solution, the concentrate must be diluted 100-200 times. To do this, 500-1000 ml of water should be added to the contents of a 5 ml vial, 1000-2000 ml of water (ordinary drinking or sterile distilled) should be added to the contents of a 10 ml vial.

The solution should be applied by irrigation or using well-soaked napkins, over which a sterile gauze pad is applied, after which it is fixed with a gauze bandage.

To dilute the concentrate in order to obtain a fat solution, you can use Castor oil, lanolin or fish oil in a ratio of 125-150 ml of any of these products for 5 ml of concentrate, 250-300 ml for 10 ml of concentrate. The resulting fatty solution of Gramicidin C is applied using soaked napkins, a sterile gauze napkin is placed on top, and then fixed with a gauze bandage.

To prepare an alcohol solution, the concentrate must be diluted 100 times with 70% ethanol (5:500 or 10:1000). The drug is used in the treatment of pyoderma, lubricating the skin 2-3 times a day.

Side effects

In some cases, the use of Gramicidin C may develop allergic reactions and contact dermatitis.

special instructions

Sick diabetes keep in mind that each tablet contains 0.05 bread units (XE).

Gramicidin C in the form of an aqueous solution can be used within 3 days from the date of preparation. It is impossible to inject solutions into a vein (phlebitis and hemolysis may develop).

drug interaction

Gramicidin C may potentiate the effects of other antimicrobial agents systemic and local action.

Analogues

An analogue of Gramicidin C is Grammidin.

Terms and conditions of storage

Store in a dark, dry place out of the reach of children.

Shelf life:

• Lozenges: 3 years at temperatures up to 25 ° C;
• Concentrate for the preparation of a solution for local and external use alcohol: 5 years at a temperature of 12-15 ° C.