How to drink tavegil for adults. Tavegil: instructions for use, analogues and reviews, prices in Russian pharmacies Tavegil indications

Tradename: Tavegil®

INN or grouping name: clemastine

Chemical Name:(2R)-2-(2-((R)-1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine (E)-butenedioate

Dosage form:

Compound:

Description. Round, flat tablets of white or almost white color with a bevelled edge. On one side of the risk pill and the engraving "FROM".

Pharmacotherapeutic group
Antiallergic - H1- histamine receptors blocker.

ATC Code: R06AA04.

Pharmacological properties
Pharmacodynamics
H1-histamine receptor blocker, ethanolamine derivative. It has a strong antihistamine and antipruritic effect with a rapid onset of action and a duration of up to 12 hours, prevents the development of vasodilation and contraction of smooth muscles induced by histamine.

Possessing an anti-allergic effect, it reduces the permeability of blood vessels, capillaries, inhibits exudation and the formation of edema, reduces itching, and has an m-anticholinergic effect.

Pharmacokinetics
After oral administration, clemastine is almost completely absorbed from gastrointestinal tract. The maximum concentration of clemastine in plasma is reached after 2-4 hours.

Communication with plasma proteins is 95%. Elimination from plasma is biphasic, with corresponding half-lives of 3.6 ± 0.9 hours and 37 ± 16 hours. Clemastine undergoes significant metabolism in the liver. Metabolites are excreted mainly through the kidneys in the urine (45 - 65%); unchanged active substance found in urine only in trace amounts. During lactation, a small amount of clemastine can pass into breast milk.

Indications for use
- Pollinosis (hay fever, including allergic rhinoconjunctivitis);
- Urticaria of various origins;
- Itching, itchy dermatoses;
- Acute and chronic eczema, contact dermatitis;
- Drug allergy;
- Insect bites.

Contraindications
Hypersensitivity, pregnancy, lactation, taking monoamine oxidase inhibitors (MAOIs), diseases of the lower respiratory tract(including bronchial asthma), childhood up to 6 years (for this dosage form).

Carefully
In patients with stenosing gastric ulcer, pyloroduodenal obstruction, with cervical obstruction Bladder, as well as prostatic hypertrophy, accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system, including arterial hypertension.

Use during pregnancy and during breastfeeding
The use of the drug during pregnancy and during breastfeeding is contraindicated.

Dosage and administration
Inside before meals, drinking water.
Adults and children over 12 years old appoint 1 tablet (1 mg) in the morning and evening. In cases that are difficult to treat, daily dose can make up to 6 tablets (6 mg).
Children aged 6-12 years appoint 1/2-1 tablet before breakfast and at night.

Side effect
Classification of the frequency of occurrence of adverse reactions:
very often (≥1/10); often (≥1/100, ≤1/10); infrequently (≥1/1000, ≤1/100); rarely (≥1/10,000, ≤1/1000); very rare (≤1/10,000).

From the side nervous system:
Often: increased fatigue, drowsiness, sedation, weakness, feeling of fatigue, lethargy, impaired coordination of movements;
Uncommon: dizziness;
Rare: headache, tremor, stimulant effect.

From the gastrointestinal tract:
Rare: dyspepsia, nausea, vomiting, gastralgia;
Very rare: constipation, dry mouth.
Isolated cases of loss of appetite and diarrhea.

From the sense organs:
Rare: blurred vision, diplopia, acute labyrinthitis, tinnitus.

From the side of the kidneys and urinary tract:
Very rare: frequent or difficult urination.

From the side respiratory system:
Rarely: thickening of bronchial secretions and difficulty in expectoration of sputum, a feeling of pressure in chest, respiratory failure, nasal congestion.

From the side of the cardiovascular system:
Rarely: lowering blood pressure (more often in older patients), extrasystole.
Very rare: palpitations.

From the blood and hematopoietic organs:
Rare: hemolytic anemia, thrombocytopenia, agranulocytosis.

From the side of the skin and subcutaneous fat:
Rare: skin rash.

From the immune system:
Rare: photosensitivity, anaphylactic shock.

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose
Symptoms. An overdose of antihistamines can lead to both inhibitory and stimulating effects on the central nervous system, the latter being more common in children. Phenomena of anticholinergic action may also develop: dry mouth, fixed dilation of the pupils, flushing of the upper half of the body, disorders of the gastrointestinal tract (nausea, epigastric pain, vomiting).

Treatment. If the patient does not vomit spontaneously, then it should be artificially induced (only if the patient's consciousness is preserved). If 3 hours or more have passed since taking the drug, it is necessary to perform a gastric lavage using a 0.9% sodium chloride solution and activated carbon. You can also prescribe a saline laxative. Symptomatic therapy is also indicated.

Interaction with other drugs
Tavegil® enhances the effect of drugs that depress the central nervous system (hypnotics, sedatives, anxiolytics), m-anticholinergics, and alcohol. Incompatible with the simultaneous use of MAO inhibitors.

special instructions
To prevent distortion of the results of skin prick tests for allergens, the drug must be discontinued 72 hours before allergy testing.

Clemastine has a slight sedative effect(from weak to moderate in intensity), therefore, persons taking Tavegil® are advised to refrain from driving vehicles, working with mechanisms, as well as from other activities that require increased concentration and psychomotor speed.

For the treatment of children over the age of 1 year, Tavegil® solution for intravenous and intramuscular administration can be used.

Tavegil® tablets contain lactose, so the drug is not recommended for patients suffering from rare congenital diseases associated with impaired galactose tolerance, severe lactase deficiency and malabsorption of glucose-galactose.

Release form
Tablets 1 mg.
On 5 tablets in the blister from the combined material (PVC/PVDC/Aluminum foil). 1, 2, 3 or 6 blisters with instructions for use in a cardboard box.
On 10 tablets in the blister from the combined material (PVC/PVDC/Aluminum foil). 1, 2, 3 or 6 blisters with instructions for use in a cardboard box.

Storage conditions
At a temperature not higher than 30 ° C.
Keep out of the reach of children.

Shelf life
5 years. Do not use after the expiration date.

Holiday conditions from pharmacies
Released without a prescription.

Registration certificate holder
Novartis Consumer Health SA
Rue de Letraz, 1260 Nyon, Switzerland

Manufacturer
Famar Italy S.p.A.
Via Zambeletti 25, 20021 Baranzate di Ballate, Italy.

Representation in Russia/Address for submitting claims
123317, Moscow, Presnenskaya emb. ten

The drug Tavegil belongs to the group of antiallergic drugs from histamine H1 receptor blockers and is prescribed to patients for the relief of allergy attacks of various origin and intensity.

Composition and form of release

Tavegil (Tavegyl) is an effective antiallergic agent. It belongs to the group of ethanolamine histamine receptor blockers, since its main active substance reduces the permeability of blood vessels.

pharmachologic effect

Tavegil has high level antihistamine action and prevents the release of active substances from fat bodies (blood cells), which provoke the development of allergic symptoms. Prevents the development of edema by reducing the permeability of the vessels of the microcirculatory circle. In this case, the drug does not cause drowsiness.

The action begins already half an hour after the first dose, and the peak is reached after 5 hours. Most often, the antihistamine effect lasts more than 12 hours, but sometimes it can last about a day.

Histamine H1 receptor blocker, ethanolamine derivative. It has a strong antihistamine and antipruritic effect with a rapid onset of action and a duration of up to 12 hours, prevents the development of vasodilation and contraction of smooth muscles induced by histamine.

Possessing an anti-allergic effect, it reduces the permeability of blood vessels, capillaries, inhibits exudation and the formation of edema, reduces itching, and has an m-anticholinergic effect.

Indications

Tavegil in the form of tablets and solution is prescribed to patients for the symptomatic treatment of the following allergic reactions:

• skin rashes;
• angioedema;
• post-vaccination allergic reactions;
• or arising during the period of active pollination and flowering of plants;
• contact dermatitis;
• year-round rhinitis;
• weeping eczema;
• atopic dermatitis;
• allergic reactions to the introduction of drugs and food;
• allergic reactions to insect bites.

The drug Tavegil in the form of tablets can be prescribed to patients prone to allergies as a preparation for vaccination.

Instructions for use

Before you start taking Tavegil, be sure to read the instructions and consult your doctor.

Tavegil tablets

1. The tablet form is taken orally twice a day at a dosage of 1 mg. The maximum allowable daily amount of Tavegil is 6 mg.
2. Children: 0.5 mg twice a day. For children from 1 to 6 years old, the medicine is prescribed in the form of syrup, 1 teaspoon. It is not recommended to use the drug under 1 year of age. Inside before meals, drinking water.
3. Adults and children over 12 years of age are prescribed 1 tablet (1 mg) in the morning and evening. In cases that are difficult to treat, the daily dose may be up to 6 tablets (6 mg).
4. Children aged 6-12 years are prescribed 1/2-1 tablet before breakfast and at night.

in ampoules

In injections, the drug is prescribed 2 times a day, 2 mg for adults, for children, intramuscular injections are performed at a rate of 25 mcg per 1 kg of body weight per day. The injection solution is produced in ampoules of 2 mg, 5 ampoules in 1 package.

Tavegil in syrup

The special syrup form makes it easier to take for children over the age of one year. The duration of therapy cannot exceed seven days, the regimen is twice / day, before meals, in the following dosage per dose:

• from one to three years - 2-2.5 ml;
• from three to six years - 5 ml;
• from six to twelve years - 5-10 ml;
• after twelve - 10 ml.

Before starting therapy, it is necessary to undergo an examination and consultation with a doctor who will adjust the dosage and set the duration of administration.

Contraindications

The main contraindications to the use of Tavegil are:

• diseases of the lower respiratory tract (including);
• simultaneous use of MAO inhibitors;
• children under 1 year of age (tablets should not be used in children under 6 years of age);
• lactation (breastfeeding);
• hypersensitivity to the components of the drug.

Age contraindications to the appointment of Tavegil for children:

• solution: up to 1 year;
• tablets: up to 6 years;
• syrup: up to 1 year.

According to the instructions, Tavegil is recommended to prescribe with caution when:

• stenotic,
• pyloroduodenal obstruction,
• prostatic hypertrophy,
• complicated by urinary retention,
• bladder neck obstruction,
• hyperthyroidism,
• increased intraocular pressure,
• and other diseases of the cardiovascular system.

Besides, with extreme caution syrup should be used for pyloric stenosis, angle-closure glaucoma.

Use during pregnancy and lactation

During pregnancy, Tavegil is used only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

should not be applied during lactation, because clemastine is excreted in small amounts in breast milk.

Side effects for the body

special instructions

1. At the time of taking the drug, strongly it is recommended to refrain from driving vehicles and other complex mechanisms, since Tavegil temporarily impairs vision and the ability to concentrate.
2. Means should not apply for at least 72 hours before allergy skin testing, as it can significantly skew the results.
3. Enhances the effect of neuroleptics(antipsychotics), hypnotics, sedatives, m-anticholinergics. Simultaneous use with MAO inhibitors is not allowed.
4. Tavegil tablets contain lactose, so the drug is not recommended for patients suffering from rare congenital diseases associated with impaired galactose tolerance, severe lactase deficiency and malabsorption of glucose-galactose.

Shelf life

Tablets should be stored in a place protected from children for no more than 4 years from the date of manufacture. Ampoule packaging should be kept in a cool, dark place out of the reach of children. The expiration date is indicated on the packaging and is 2 years from the date of manufacture, provided that the ampoules are properly stored.

Terms of dispensing from pharmacies

The drug Tavegil can be bought at a pharmacy without a doctor's prescription.

Analogues

To analogues medicinal product Tavegyl, which also help with allergic ailments, includes such remedies:

• clemastine,
• Suprastin,
• Diphenhydramine,
• Pipolfen,
• Benadryl and other medicines.

Prices in pharmacies

In pharmacies in Russia, the medicine is sold upon presentation of a prescription from a doctor at the following cost:

• 10 tablets with a dose of 1 mg - about 120 rubles;
• a package of 20 tablets with a dosage of 1 mg each - an average of 170 rubles;
• ampoules with a solution for injections (injections) of 2 ml - no more than 190 rubles per pack of 5 ampoules.

Medicine Tavegil is included in the category of medicines with antiallergic action. It has the ability to block histamine receptors and prevent the development of an allergic reaction. Quite often, the drug is prescribed to patients in order to eliminate the various reactions of the body to the activity of allergens.

Before we talk about how to take Tavegil, let's look at the composition and form of the drug. This medication is made in the form of tablets for oral administration and a special injection solution. Such tablets are white in color and are packed in a special blister. One blister may contain five or ten tablets.

As part of the drug, such a component as "Clemastin" acts as an active substance. Other ingredients include magnesium stearate, povidone, lactose monohydrate, and corn starch.

Tavegil refers to pharmacological group drugs that can act on H1 receptors that trigger an allergic chain reaction in the human body

The solution for injection is poured into special ampoules made of transparent glass. Each ampoule contains five milligrams of a colorless liquid. At the heart of this form of the drug, there is also an active substance. Differences between drugs are observed only in auxiliary components. In solution, sodium citrate dihydrate, ethanol, propylene glycol, injection water and sorbitol act as additional substances.

When the medicine is applied

The main purpose of the drug is to relieve allergies. Let's look at what Tavegil helps from:

• eliminates allergic rash;
• relieves angioedema;
• reduces the severity of an allergic reaction to insect bites, when eating products and using medicines.

In addition, the drug is prescribed for diseases such as weeping eczema, urticaria, contact or atopic dermatitis, perennial rhinitis and conjunctivitis. People who are prone to allergies are advised to use the remedy as a medicine that prepares for the vaccination procedure. Tavegil tablets can also be used to eliminate post-vaccination allergic reactions.

Before you start using the medication, you need to study the annotation to the remedy in detail. Instructions for use of the drug states that it has certain contraindications. So it is not recommended to use the medication for the following purposes:

1. Do not use the solution for children under the age of one year.
2. It is not recommended to use tablets for children under the age of six years.
3. It is necessary to refuse the use of the drug in case of individual intolerance and hypersensitivity to the composition.

In addition, with caution, the use of the drug should be approached by women during pregnancy and lactation. Also, experts say that the medication is unacceptable for people who have such a chronic disease as bronchial asthma. The contraindications of the solution include diseases such as glaucoma, which has a closed-coal form, disruption internal organs, problems with blood vessels and the prostate gland, as well as hyperthyroidism and anuria. With special care, the use of the drug should be approached by older people.

Tavegil instructions for use in children also talk about special measures use of this tool. It is very important to observe the correct dosage, as its violation can lead to various complications.

Scheme of administration and dosage

Since the drug is used to relieve allergy attacks, the dosage regimen and dosage are prescribed individually. Based on the severity of the body's reaction to the allergen, the doctor selects the release form of Tavegil, which will be used for therapy. To determine the dose, parameters such as weight, age, the nature of the severity of the pathology and other characteristics of the body are taken into account.

For the treatment of children over twelve years of age and adults, the following regimen is recommended. During the day, the patient should take one tablet of the drug in the morning and evening. In a severe form of an allergic reaction, the dosage can be increased to six tablets per day. It is not recommended to exceed this rate, since there is a high probability of complications arising from an overdose of the drug.

Children over the age of six years should take half a tablet twice a day. The maximum daily dose at this age is three tablets. The solution can also be used by both adults and children. Injections should be made intramuscularly or intravenously.

In most cases, doctors prescribe injections of two milliliters twice a day. In some cases, it is allowed to dilute the drug with ten milliliters of sodium chloride solution. This need is most often seen in intravenous administration medication.

For the treatment of children under one year of age, the dosage is calculated on the basis of weight. So, if you need to use the drug, you need to take into account that zero point twenty-five hundredths of a milligram is used per kilogram of body weight. The received dose should be divided into two injections, which are given in the morning and in the evening. It is important to clarify that infants are given medication only intramuscularly.

Pregnancy and breastfeeding

Tavegil tablets instructions for use by adults, which indicate the absence of clinical trials of side effects during pregnancy, should not be used when breastfeeding. Experts have not established how the components of this drug affect the development of the fetus and the growing organism.

Since the composition enters the bloodstream, some components may pass into the composition of breast milk. What this situation will lead to is unknown, therefore, if there is a strong need to use the medication, the child should first be transferred to feeding with artificial mixtures.

Side effects

Side effects from the use of the drug are observed quite rarely. In most cases, their appearance is associated with a violation medical advice and increasing the dose. Also, the appearance of side effects of the drug may be affected by intolerance to certain components of the composition or hypersensitivity. In rare cases side effects may be associated with a long course of treatment.

Side effects of Tavegil can be expressed in the appearance of symptoms such as severe fatigue and apathy, attacks of headache and dizziness, problems with concentration and asthenia. Quite often, patients complain that while taking the medication, a cough and other disorders of the respiratory organs appear.

The organs of the gastrointestinal tract are particularly susceptible to the composition of Tavegil. Against this background, such unpleasant symptoms as a feeling of dry mouth, constant thirst may appear.

Violation of the dosage can cause feelings of nausea, diarrhea and vomiting, as well as acute pain in the abdomen.

Among the side effects of the solution, it is necessary to highlight the problems associated with the action of the cardiovascular system. So against the background of intravenous injections, attacks of tachycardia and a strong decrease in blood pressure can be observed. An overdose can cause swelling of the mucous membrane, the appearance of a rash and even anaphylactic shock. When administered intramuscularly, the patient may experience severe pain, and a hematoma forms at the injection site. Such side effects require an immediate stop to the course of treatment and seeking help from a specialist.

Overdose and combinations with other drugs

In order to avoid an overdose, you must carefully follow the doctor's recommendations. Tavegil from allergies in case of an overdose can cause symptoms such as:

• increased drowsiness;
• problems with heart rhythm;
• collapse;
• asthma attacks;
• a sharp decrease in blood pressure;
• loss of consciousness.

In the event of a similar situation, immediate hospitalization of the patient is required for symptomatic therapy.

Speaking about medicinal combinations of Tavegil with other drugs, experts highlight several nuances. So it is unacceptable to use the drug in combination with such drug groups as: analgesics, sedatives, MAO inhibitors and tranquilizers. You also need to be careful when using Tavegil in combination with sleeping pills. Such a combination can significantly enhance the therapeutic effect of hypnotic drugs, which can lead to various complications.

Experts highlight another nuance associated with Tavegil. So taking the drug in combination with antacid medicines and enterosorbents can cause a decrease in the effect of Tavegil. When using such a combination, you should carefully consider this factor. It is best to make a small time interval between the use of these funds.

Before using the drug Tavegil for the treatment of allergic diseases, it is recommended to conduct a comprehensive diagnosis of the body. In some cases, the use of the drug can cause problems with the liver and disruption of the functioning of the central nervous system. This situation is most often observed against the background of the simultaneous administration of medication and alcohol.

Tavegil, in the form of a solution for injection, should not be used for minor allergies. To eliminate a mild reaction of the body, it is enough to use tablets. In case of integrity damage skin, purulent rashes and open sores on those parts of the body that are used for injection, it is best to refuse injections.

Before injecting the solution, you must first warm the ampoule to the temperature of the human body, holding it in the palm of your hand for several minutes. The tool has its own expiration date and special storage recommendations. Failure to follow these rules can lead to the fact that a precipitate will appear at the bottom of the solution. Such a drug is prohibited.

During the course of treatment, you should refrain from driving and other activities that require prolonged concentration of attention. Taking the medication may be accompanied by a feeling of severe fatigue and drowsiness, as well as bouts of dizziness.

Where to buy Tavegil and its analogues

Let's look at how much Tavegil costs and what analogues this medication has. The drug Tavegil can be purchased at many pharmacies in Russia. Its price is about one hundred and fifty rubles for a pack of tablets and about five hundred rubles for an injection solution. The medicine is dispensed without a medical prescription.

It is very important to follow the recommendations for storing the medicine. Tablets can be used within four years from the date of their production, only under proper storage conditions. Store the medicine in a cool place, away from direct sunlight. The same recommendations apply to the solution. The shelf life of the solution is two years from the date of production. All the necessary information on the use of the drug is available in the annotation.

Analogues of the drug are most often used for hypersensitivity or individual intolerance to the drug. These include Zodak and Zirtek drops, Chloropyramine and Subrestin solutions, Suprastin and Loratadin tablets. For the treatment of children, you can use the remedy "Claritin" in the form of a syrup.

Every year more and more people suffer from allergic manifestations, this problem is familiar to every third inhabitant of the planet. The reason is the external environment, ecology, bad habits and low-quality food used for food. The immune system It defends itself against irritants by producing antibodies, which in each person are manifested by intolerance to a particular product, compound or substance.

Tavegil is a high action antiallergic drug with anticholinergic and antihistamine effects. It helps with mild and moderate manifestations of allergies, in serious cases only injections are effective. Consider the form in which the drug is produced, how it works, how it is used and possible contraindications.

In what form is the drug produced and what does it consist of

The drug Tavegil is available in the form of syrup, tablets and solution for intramuscular injection. The main active ingredient is Clemastine hydrofumarate + excipients.

• Syrup. The volume of the bottle varies from 60 to 100 ml;
• Pills 1 or 2 blisters per pack;
• injection solution Tavegil in ampoules.

The syrup is effective for mild manifestations of allergies. Due to the flavorings, the liquid has a pleasant taste, which makes it possible to easily give the drug to young children.

1 tablet of Tavegil contains 1 mg of the main substance, plus additional components: povidone, magnesium, lactose monohydrate, etc. Recommended for adults.

Injections are also used in severe cases of allergies, for example, with edema and asphyxia. In 1 ml. liquids - 1 ml. active component drug.

The form of the drug is prescribed individually, depending on age, general condition health of the body and the degree of manifestation of the disease.

How exactly does Tavegil work?

If a person is susceptible to allergies, histamine begins to be produced upon contact or ingestion of the allergen.

Allergies are divided into the following types:

• food;
• for medicinal components;
• contact;
• respiratory.

Regardless of the variety, biologically active histamine causes a runny nose, itching, coughing, swelling, or other manifestations. Clemastine, contained in the Tavegil preparation, suppresses the production of histamine and dampens its activity, reducing the absorbent function of the circulatory system. Allergy symptoms are suppressed and do not develop further. The action of Tavegil is expressed in the disappearance of itching and swelling, normalization of breathing, etc.

In what cases is the medication prescribed

Tavegil has won the trust of many experts and is actively used in medicine. It is prescribed to get rid of the following symptoms and diseases:

• rash - occurs as redness or blisters with liquid, with contact allergies or after eating certain foods;
• inflammation and redness of the mucous membranes;
• runny nose, increased mucus production. Often found in spring and summer, during the flowering period of plants;
• hives;
• conjunctivitis, if the inflammation is activated by plant pollen;
• itching after insect bites or contact with pets;
• asphyxia after exposure to pharmacological drugs;
• eczema, chronic or local, in the acute stage;
• anaphylactic shock.

The drug Tavegil acts quickly and covers all body systems. In emergency cases, intramuscular injections are recommended, with sluggish manifestations, oral administration is sufficient.

The purchase of the drug is possible both with a prescription from the treating allergist, and without a document. It is forbidden to take medicine without consulting a doctor, since the effect of Clemastin on the body can be unpredictable. If the treatment is prescribed by a doctor, you should be warned that young children are only allowed to take syrup.

Instructions for use of Tavegil tablets

Rules for taking Tavegil medicine for children

Observe the minimum allowable age of the child at which the medication does not harm - 1 year. Be sure to use the measuring cup that is in the package, it is important not to violate the dosage. For children under 3 years of age, the drug is allowed twice a day (morning and evening, 15-20 minutes before meals). 1 dose - 2-2.5 ml.

Starting from the age of three, and up to 6 years, one dose includes 5 ml of therapeutic liquid.

Toddlers of primary school age and up to 12 years old can take 5 ml twice a day in cases where the effect of the medicine is sufficient and the allergy is mild. In severe cases, it is allowed to increase the dosage to 10 ml twice a day.

The action of the drug is almost instantaneous and very strong, lasting no longer than 8 hours. If the course is delayed longer than 3 weeks, you need to visit a doctor and consult on a replacement medication. This is necessary, since the body gets used to the drug, Tavegil ceases to produce the proper antihistamine effect.

For adults, taking the drug twice a day, before meals

It is preferable for adults to opt for Tavegil tablets, which are taken twice a day, before meals. The medicine does not need to be chewed, it is enough to swallow and drink plenty of water. If the allergy has worsened, it is permissible to drink 5-6 pills per day, but only in emergency cases.

In situations where intramuscular administration is necessary, 2 ml of the drug is drawn into the syringe. Tavegil warms up in the palms room temperature. It can be administered intravenously, but only in cases where it can save a person's life. Such procedures are recommended to be carried out strictly in medical institutions and under medical supervision.

Possible side effects and overdose

If you strictly follow the course and dosage, the side effect of the drug Tavegil occurs in exceptional cases. More often it is faced by people with individual intolerance, high sensitivity to drugs or those who take the drug for a long period of time.

Possible side effects:

• dryness in lying, thirst;
• dysfunction of urination;
• skin rash, swelling of the mucous membranes and increased mucus formation;
• severe, dry cough, respiratory failure;
• nasal congestion;
• anemia;
• headache, weakness, dizziness, fainting;
• constant sleepy state and apathy towards others, detachment;
• lack of appetite;
• overexcited state;
• problems in the work of the gastrointestinal tract: discomfort in the abdomen, vomiting, problems with the stool;
• tachycardia, low blood pressure, It's a dull pain in the region of the heart;

If Tavegil was administered intramuscularly, small hematomas may occur at the injection site, which in some cases itch.

If you are undergoing treatment with Tavegil and have encountered at least one of the listed side effects, immediately contact an allergist and ask to change the medicine to another medication.

In case of an overdose of the drug, malfunctions in the central nervous system may occur: the patient is in a constantly excited state, sleep is disturbed. Or, on the contrary, the sedative effect increases, the person is depressed and sleeps for a long time. There have been cases of hallucinations and seizures.

Contraindications for use

Tavegil is strictly prohibited for newborn children and women during pregnancy and lactation. It has a number of health contraindications, in which the drug should be handled very carefully:

• respiratory diseases, bronchial asthma;
• problems with the cardiovascular system and pressure;
• chronic diseases of the gastrointestinal tract in the acute stage;
• angle-closure glaucoma;
• liver disease and kidney failure;
• parallel treatment with MAO inhibitors - antidepressants;
• age over 65 years.

Allergic people must first make sure that they do not have hypersensitivity to the components of the drug, Tavegil, being an antihistamine medication, does not guarantee complete safety.

How does the drug interact with other drugs

If Tavegil treatment coincides with other recovery programs, course adjustment should be made by a specialist. It is not recommended to combine Tavegil tablets with painkillers, sedatives and antidepressants. Interaction with sleeping pills is strictly prohibited, since Tavegil has an intensifying effect - it can be life-threatening.

The joint use of the drug and alcohol is prohibited, it can cause Negative consequences for the body

It is not allowed to take clemastine hydrofumarate together with alcohol, since the drug actively affects the brain. At the same time, the effect of alcohol is approximately doubled. The desire to drink can turn into clouding of consciousness and severe incoordination, therefore, trauma. And in the morning, any hangover will become unbearable, even with a small amount of alcohol consumed the day before.

Analogues of the drug Tavegil

If you are prescribed Tavegil, but its effect seems insufficient to you or causes side effects, you should consider changing the medication. It is not safe to do this on your own, check with your doctor before making a decision.

Known analogues of Tavegil:

• Loratadine.

The listed pharmaceuticals are similar in their effect, but each of them has individual side effects and nuances of administration.

Based on the practice of doctors and reviews of people susceptible to all kinds of allergens, we can conclude that Tavegil is known for its milder effect, in contrast to the advertised Suprastin.

The cost of the medicine ranges from 120 to 300 rubles, the price depends on the form of release.

Active substance

Clemastine (clemastine)

Release form, composition and packaging

◊ Pills white or almost white, round, flat, with a beveled edge, with a line and engraved "FROM" on one side.

Excipients: lactose monohydrate - 107.66 mg, corn starch - 10.8 mg, talc - 5 mg, - 4 mg, magnesium stearate - 1.2 mg.

5 pieces. - blisters (2, 3, 6) - packs of cardboard.
10 pieces. - blisters (1, 2, 3, 6) - packs of cardboard.

pharmachologic effect

Histamine H1 receptor blocker, ethanolamine derivative. It has a strong antihistamine and effect with a rapid onset of action and a duration of up to 12 hours, prevents the development of vasodilation and contraction of smooth muscles induced by histamine.

Possessing an anti-allergic effect, it reduces the permeability of blood vessels, capillaries, inhibits exudation and the formation of edema, reduces itching, and has an m-anticholinergic effect.

Pharmacokinetics

Suction

After oral administration, it is almost completely absorbed from the gastrointestinal tract. Cmax in blood plasma is reached in 2-4 hours.

Distribution

The binding of clemastine to plasma proteins is 95%. It is excreted in breast milk in small quantities.

Metabolism and excretion

Excretion from has a two-phase character, the corresponding T 1/2 is 3.6 ± 0.9 h and 37 ± 16 h. Clemastine undergoes significant metabolism in the liver. Metabolites are mainly (45-65%) excreted in the urine; unchanged active substance is found in the urine only in trace amounts.

Indications

• pollinosis (hay fever, including allergic rhinoconjunctivitis);
• urticaria of various origins;
• itching, itchy dermatoses;
• acute and chronic eczema, contact dermatitis;
• drug allergy;
• insect bites.

Contraindications

• diseases of the lower respiratory tract (including bronchial asthma);
• simultaneous use of MAO inhibitors;
• children's age up to 6 years;
• pregnancy;
• lactation (breastfeeding);
• hypersensitivity to the components of the drug.

With caution Tavegil should be used in patients with stenosing gastric ulcer, with pyloroduodenal obstruction, with obstruction of the bladder neck, as well as prostatic hypertrophy, accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system (including arterial hypertension).

Dosage

inside adults and children over 12 years old appoint 1 tab. (1 mg) morning and evening. In cases that are difficult to treat, the daily dose can be up to 6 tablets. (6 mg).

Children aged 6-12 years appoint 1/2-1 tab. before breakfast and at night.

Tablets should be taken before meals with water.

Side effects

Determining the frequency of adverse reactions: very often (≥1 / 10); often (≥1/100,<1/10); нечасто (≥1/1000, <1/100); редко (≥1/10 000, <1/1000); очень редко (<1/10 000).

From the nervous system: often - increased fatigue, drowsiness, sedation, weakness, feeling of fatigue, lethargy, impaired coordination of movements; infrequently - dizziness; rarely - headache, tremor, stimulating effect.

From the digestive system: rarely - dyspepsia, nausea, vomiting, gastralgia; very rarely - constipation, dry mouth; in some cases - loss of appetite, diarrhea.

From the respiratory system: rarely - thickening of bronchial secretions and difficulty in sputum separation, a feeling of pressure in the chest and difficulty breathing, nasal congestion.

From the side of the cardiovascular system: rarely - lowering blood pressure (more often in older patients), extrasystole; very rarely - palpitations.

From the sense organs: rarely - a violation of the clarity of visual perception, diplopia, acute labyrinthitis, tinnitus.

From the urinary system: very rarely - frequent urination, difficulty urinating.

From the hematopoietic system: rarely - hemolytic anemia, thrombocytopenia, agranulocytosis.

Dermatological reactions: rarely - skin rash, photosensitivity.

Allergic reactions: rarely - anaphylactic shock.

Overdose

Symptoms: an overdose of antihistamines can lead to both inhibitory and stimulating effects on the central nervous system. CNS stimulation is more common in children. Manifestations of anticholinergic action may also develop: dry mouth, fixed pupillary dilation, rush of blood to the upper half of the body, gastrointestinal disorders (nausea, epigastric pain, vomiting).

Treatment: if the patient does not vomit spontaneously, then it should be artificially induced (only if the patient's consciousness is preserved). If 3 hours or a little more have passed since taking the drug, gastric lavage can be performed using isotonic solution. You can also prescribe a saline laxative. Symptomatic therapy is also indicated.

drug interaction

Tavegil potentiates the action of drugs that depress the central nervous system (hypnotics, sedatives, tranquilizers), m-anticholinergics, and ethanol.

Incompatible with the simultaneous use of MAO inhibitors.

special instructions

To prevent distortion of the results of skin prick tests for allergens, the drug must be discontinued 72 hours before allergy testing.

The tablets contain lactose, so the drug is not recommended for patients suffering from rare congenital diseases associated with galactose intolerance, severe lactase deficiency and malabsorption of glucose-galactose.

Pediatric use

Tavegil in the form of tablets is contraindicated in children under the age of 6. For treatment of children over the age of 1 year Tavegil can be used in the form of a solution for intravenous and intramuscular administration.

Influence on the ability to drive vehicles and control mechanisms

Clemastine has a slight sedative effect (from mild to moderate in intensity), so patients taking Tavegil are advised to refrain from driving vehicles, working with mechanisms, as well as from other activities that require increased attention and speed of psychomotor reactions.

The drug should be stored out of the reach of children at a temperature not exceeding 30 ° C. Shelf life - 5 years.