What helps "Vilprafen". Instructions, price and analogues. Vilprafen suppositories instructions for use What are vilprafen tablets

The composition of 1 tablet includes the active substance josamycin, in the amount of 500 mg.

Auxiliary components in 1 tablet: polysorbate 80 - 5 mg; magnesium stearate - 5 mg; microcrystalline cellulose - 101 mg; colloidal silicon dioxide - 14 mg; carmellose sodium - 10 mg.

Shell composition: polyethylene glycol 6000 - 0.3846 mg; methylcellulose - 0.12825 mg; titanium dioxide - 0.641 mg; talc - 2.0513 mg; copolymer of methacrylic acid and its esters - 1.15385 mg; aluminum hydroxide - 0.641 mg.

Vilprafen is produced in the form of film-coated tablets - biconvex, oblong, almost white or white, with risks on both sides (10 pieces in blisters, 1 blister in a cardboard box).

Description of the dosage form

Macrolide antibiotic.

Characteristic

Vilprafen is an antibiotic of the macrolide group of bactericidal action.

Pharmacokinetics

After oral administration, josamycin is absorbed from the gastrointestinal tract at a high rate, food intake does not change its bioavailability. The maximum concentration of the substance in plasma is reached 1 hour after ingestion. When taking Vilprafen at a dose of 1 g, its maximum level active substance in blood plasma is 2–3 μg / ml. The degree of binding of josamycin to plasma proteins is approximately 15%. The compound is well distributed in tissues and organs (excluding the brain), and its concentrations often exceed plasma levels and retain therapeutic efficacy for a long time. Especially high concentrations of josamycin are found in lacrimal fluid, saliva, sweat, tonsils and lungs. Its content in sputum exceeds the content in plasma by 8-9 times.

Josamycin crosses the placental barrier and passes into breast milk. The compound is metabolized in the liver, forming metabolites with less pharmacological activity. Josamycin is excreted primarily in the bile. Its half-life is 1-2 hours, but this figure may be prolonged in patients with liver dysfunctions. The degree of excretion of the drug in the urine does not exceed 10%.

Pharmacodynamics

The mechanism of action of josamycin is to prevent the production of protein in the microbial cell, which is explained by reversible binding to the 50S subunit of the ribosome. Usually at therapeutic concentrations for active component The drug is characterized by a bacteriostatic effect, which leads to inhibition of the growth and reproduction of bacteria. If high concentrations of josamycin are created in the inflammatory focus, manifestations of a bactericidal effect are observed.

Josamycin is active against the following microorganisms:

• Gram-positive bacteria: Staphylococcus spp. (including strains of Staphylococcus aureus sensitive to methicillin), Peptostreptococcus spp., Streptococcus spp. (including Streptococcus pneumoniae and Streptococcus pyogenes), Peptococcus spp., Corynebacterium diphtheriae, Clostridium spp., Listeria monocytogenes, Bacillus anthracis, Propionibacterium acnes;
• gram-negative bacteria: Campylobacter jejuni, Neisseria gonorrhoeae, Neisseria meningitides, Helicobacter pylori, Moraxella catarrhalis, Haemophilus influenzae, Haemophilus ducreyi, Legionella spp., Brucella spp., Bordetella spp.;
• others: Borrelia burgdorferi, Bacteroides fragilis (josamycin sensitivity may be variable), Treponema pallidum, Chlamydia spp. (including Chlamydia trachomatis), Ureaplasma spp., Mycoplasma spp. (including Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae), Chlamydophila spp. (including Chlamydophila pneumoniae).

Enterobacteria are usually resistant to josamycin, so its use has little effect on the microflora. gastrointestinal tract(GIT). The active substance also demonstrates activity in diagnosed resistance to erythromycin and other 14- and 15-membered macrolides. Cases of resistance to josamycin are less common than to 14- and 15-membered macrolides.

Instruction

Vilprafen is taken orally between meals. The tablet should be swallowed whole and washed down with a small amount of water.

For teenagers aged 14 years and older and adults recommended daily dose is 1-2 g of Vilprafen, which must be divided into 2-3 doses. The initial recommended dose is 1 g.

With spherical and common acne, during the first 2-4 weeks, 0.5 g of josamycin is prescribed 2 times a day, then for 2 months the frequency of use is reduced to 0.5 g of josamycin 1 time per day (as maintenance therapy).

The duration of treatment is usually determined by the doctor. According to the recommendations of the World Health Organization on the use of antibiotic drugs, the duration of therapy for streptococcal infections should be at least 10 days.

If one dose of Vilprafen is missed, a dose should be taken immediately. In cases where it is time for the next dose of the drug, the dose should not be increased.

A break in therapy or premature discontinuation of the drug reduces the likelihood of successful treatment.

Indications for use Vilprafen

Vilprafen 500 mg tablets are prescribed for the treatment of infectious and inflammatory diseases caused by action-sensitive active substance(josamycin) microorganisms:

• lower end infections respiratory tract – acute bronchitis, whooping cough, bronchopneumonia, psittacosis, pneumonia, including atypical form;
• ENT infections and upper divisions respiratory tract - sinusitis, tonsillitis, paratonsillitis, pharyngitis, otitis media, laryngitis;
• Oral infections - periodontal disease and gingivitis;
• Scarlet fever (with hypersensitivity to penicillin);
• Diphtheria (in addition to therapy with diphtheria antitoxin);
• Genital infections and urinary tract- prostatitis, urethritis, gonorrhea; with hypersensitivity to penicillin - venereal lymphogranuloma, syphilis;
• Mycoplasma (including ureaplasma), chlamydial and mixed infections of the genital organs and urinary tract;
• Infections of soft tissues and skin - lymphadenitis, lymphangitis, boils, pyoderma, acne, anthrax, erysipelas(with hypersensitivity to penicillin).

Contraindications to the use of Vilprafen

Heavy functional disorders liver. Hypersensitivity to the components of the drug and other antibiotics of the macrolide group.

Vilprafen Use during pregnancy and children

Breastfeeding and pregnant women can only take Vilprafen in cases where the expected benefit to the mother's health exceeds possible risk for the fetus or child.

Wilprafen side effects

While taking Vilprafen, development of disorders from the side is possible. various systems body:

• Gastrointestinal tract: rarely - heartburn, nausea, loss of appetite, diarrhea and vomiting. In severe persistent diarrhea, the possibility of pseudomembranous colitis (life-threatening) due to the action of an antibiotic should be borne in mind;
• Hearing aid: in rare cases, dose-dependent transient hearing loss;
• Bile ducts and liver: in some cases - a transient increase in the activity of liver enzymes in the blood plasma, sometimes accompanied by jaundice and a violation of the outflow of bile;
• Hypersensitivity reactions: in some cases - skin allergic reactions(for example, urticaria).

drug interaction

The simultaneous use of Vilprafen with cephalosporins and penicillins should be avoided.

When used together with lincomycin, the effectiveness of both drugs may decrease.

Vilprafen slows down the elimination of theophylline to a lesser extent than other antibiotic drugs of the macrolide group.

With simultaneous use with cyclosporine, it is possible to increase its concentration in blood plasma up to nephrotoxic.

There are reports of an increase in vasoconstrictor action with the combined use of ergot alkaloids, antibiotics and drugs of the macrolide group.

Vilprafen slows down the excretion of astemizole or terfenadine, which increases the risk of developing life-threatening arrhythmias.

With simultaneous use with digoxin, an increase in the level of the latter in the blood plasma is possible.

With the simultaneous use of the drug with hormonal means contraception additionally it is necessary to use non-hormonal contraceptives.

Dosage of Wilprafen

Vilprafen is prescribed orally.
For adults and children over 14 years of age, Vilprafen is prescribed in a daily dose of 1-2 g (suspension or tablets), usually in 3 doses (the first dose should be at least 1 g) between meals, the tablets are washed down with a small amount of liquid, swallowed whole. Vilprafen dispersible tablets are pre-dissolved in water.
For infants and children under 14 years of age, it is preferable to prescribe Vilprafen in the form of a suspension. The recommended daily dose of Vilprafen for newborns and children under 14 years of age is 30-50 mg / kg of body weight, divided into three doses. In newborns and children under 3 months of age, the dose of Vilprafen should be selected exactly based on the child's body weight.

Overdose

To date, information on the specific symptoms of an overdose of Vilprafen is practically absent. In this case, it is worth assuming an increase in the severity of adverse reactions of the drug, mainly from the gastrointestinal tract.

Precautionary measures

With the development of pseudomembranous colitis, Vilprafen should be discontinued and appropriate treatment prescribed. It is contraindicated to take drugs that reduce intestinal motility.

Sick with kidney failure it is necessary to adjust the dosing regimen in accordance with the values ​​of creatinine clearance (CC).

According to the instructions, Vilprafen is not prescribed to premature babies. When used in newborns, liver function should be monitored.

It is necessary to take into account the possibility of cross-resistance to various antibiotic drugs of the macrolide group.

It has been established that the use of Vilprafen does not affect the ability to manage vehicles and perform potentially dangerous types of work associated with increased concentration and quick reactions.

Published on this page detailed instructions by application Wilprafen. Available dosage forms drug (tablets 500 mg and 1000 mg Solutab), as well as its analogues. Information is provided on the side effects that Vilprafen can cause, on interactions with other drugs. In addition to information about the diseases for the treatment and prevention of which are prescribed medicine(acne, ureaplasma, chlamydia and other infectious pathogens), the algorithms for admission, possible dosages for adults and children are described in detail, the possibility of use during pregnancy and lactation is specified. Annotation to Vilprafen is supplemented by reviews of patients and doctors.

Instructions for use and dosage

Children aged 1 year have an average body weight of 10 kg.

The daily dose for children with a body weight of at least 10 kg is prescribed on the basis of 40-50 mg / kg of body weight daily, divided into 2-3 doses: children with a body weight of 10-20 kg are prescribed 250-500 mg (1 / 4-1/2 tablets dissolved in water) 2 times a day, children weighing 20-40 kg are prescribed 500-1000 mg (1/2-1 tablets dissolved in water) 2 times a day, children weighing body over 40 kg - 1000 mg (1 tablet) 2 times a day.

Usually the duration of treatment is determined by the doctor and ranges from 5 to 21 days, depending on the nature and severity of the infection. In accordance with WHO recommendations, the duration of treatment for streptococcal tonsillitis should be at least 10 days.

In the schemes of antihelicobacter therapy, Vilprafen is prescribed at a dose of 1 g 2 times a day for 7-14 days in combination with other drugs in their standard doses:

• famotidine 40 mg daily or ranitidine 150 mg twice daily + josamycin 1 g twice daily + metronidazole 500 mg twice daily;
• omeprazole 20 mg (or lansoprazole 30 mg, or pantoprazole 40 mg, or esomeprazole 20 mg, or rabeprazole 20 mg) twice daily + amoxicillin 1 g twice daily + josamycin 1 g twice daily;
• omeprazole 20 mg (or lansoprazole 30 mg or pantoprazole 40 mg or esomeprazole 20 mg or rabeprazole 20 mg) twice daily + amoxicillin 1 g twice daily + josamycin 1 g twice daily + bismuth tripotassium dicitrate 240 mg 2 times a day;
• famotidine 40 mg daily + furazolidone 100 mg twice daily + josamycin 1 g twice daily + bismuth tripotassium dicitrate 240 mg twice daily).

In the presence of atrophy of the gastric mucosa with achlorhydria, confirmed by pH-metry: amoxicillin 1 g 2 times a day + josamycin 1 g 2 times a day + bismuth tripotassium dicitrate 240 mg 2 times a day.

Vilprafen Solutab tablets can be taken in various ways: the tablet can be swallowed whole with water or previously, before taking, dissolved in water. Tablets should be dissolved in at least 20 ml of water. Before taking, the resulting suspension should be thoroughly mixed.

When taking Vilprafen, it should be borne in mind that if one dose is missed, you must immediately take a dose of the drug. However, if it is time to take the next dose, you should not take the missed dose, you should return to the usual treatment regimen. Do not double dose. Interruption in treatment or premature discontinuation of the drug reduces the likelihood of success of therapy.

Release forms

Tablets 500 mg and 1000 mg (Vilprafen Solutab).

Wilprafen- an antibacterial drug from the group of macrolides. The mechanism of action is associated with impaired protein synthesis in the microbial cell due to reversible binding to the 50S subunit of the ribosome. In therapeutic concentrations, as a rule, it has a bacteriostatic effect, slowing down the growth and reproduction of bacteria. When creating high concentrations in the focus of inflammation, a bactericidal effect is possible.

Josamycin (the active ingredient of Vilprafen) is active against gram-positive and gram-negative bacteria.

As a rule, it is not active against enterobacteria, therefore, it slightly affects the microflora of the gastrointestinal tract. In some cases, it remains active with resistance to erythromycin and other 14- and 15-membered macrolides (streptococci, staphylococci). Resistance to josamycin is less common than to 14- and 15-membered macrolides.

Pharmacokinetics

After oral administration, Vilprafen is rapidly absorbed from the gastrointestinal tract. Eating does not affect bioavailability. Josamycin is well distributed in organs and tissues (with the exception of the brain), creating concentrations exceeding plasma levels and remaining at a therapeutic level for a long time. Josamycin creates especially high concentrations in the lungs, tonsils, saliva, sweat and lacrimal fluid. The concentration in sputum exceeds the concentration in plasma by 8-9 times. Passes the placental barrier, is secreted into breast milk. Excreted mainly with bile, excretion with urine does not exceed 10%.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• infections of the upper respiratory tract and ENT organs (pharyngitis, tonsillitis, paratonsillitis, laryngitis, otitis media, sinusitis);
• diphtheria (in addition to treatment with diphtheria antitoxin);
• scarlet fever (with hypersensitivity to penicillin);
• lower respiratory tract infections (acute bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia, including those caused by atypical pathogens);
• whooping cough;
• psittacosis;
• oral infections (gingivitis, pericoronitis, periodontitis, alveolitis, alveolar abscess);
• eye infections (blepharitis, dacryocystitis);
• infections of the skin and soft tissues (folliculitis, furuncle, furunculosis, abscess, acne, lymphangitis, lymphadenitis, phlegmon, panaritium, wound / including postoperative / and burn infections);
• anthrax;
• erysipelas (with hypersensitivity to penicillin);
• infections of the urinary tract and genital organs (urethritis, cervicitis, epididymitis, prostatitis caused by chlamydia and / or mycoplasmas);
• venereal lymphogranuloma;
• gonorrhea, syphilis (with hypersensitivity to penicillin);
• gastrointestinal diseases associated with Helicobacter pylori (including gastric ulcer and duodenum, chronic gastritis).

Contraindications

• severe liver dysfunction;
• children weighing less than 10 kg;
• hypersensitivity to the components of the drug;
• hypersensitivity to macrolide antibiotics.

special instructions

In the case of persistent severe diarrhea, the possibility of developing life-threatening pseudomembranous colitis against the background of josamycin should be borne in mind.

In patients with renal insufficiency, treatment should be carried out taking into account the results of appropriate laboratory tests (determination of endogenous creatinine clearance).

Consideration should be given to the possibility of cross-resistance to various antibiotics from the macrolide group (microorganisms that are resistant to treatment with antibiotics related in chemical structure may also be resistant to josamycin).

Side effect

• discomfort in the stomach;
• nausea;
• abdominal discomfort;
• vomit;
• diarrhea, constipation;
• stomatitis;
• loss of appetite;
• pseudomembranous colitis;
• hives;
• angioedema;
• anaphylactoid reaction;
• bullous dermatitis;
• erythema multiforme exudative (including Steven-Johnson syndrome);
• jaundice;
• dose-dependent transient hearing loss;
• purpura.

drug interaction

Because bacteriostatic antibiotics can reduce the antimicrobial effect of bactericidal antibiotics, their joint administration should be avoided. Vilprafen should not be administered in conjunction with lincosamides, because a mutual decrease in their effectiveness is possible.

Some representatives of the macrolide group slow down the elimination of xanthines (theophylline), which can lead to signs of intoxication. Clinical and experimental studies indicate that josamycin has less effect on theophylline elimination than other macrolides.

With the joint appointment of Vilprafen and antihistamines containing terfenadine or astemizole, the risk of developing life-threatening arrhythmias may increase.

There are separate reports of increased vasoconstriction after the joint appointment of ergot alkaloids and antibiotics from the macrolide group, incl. a single observation while taking josamycin.

Co-administration of josamycin and cyclosporine may cause an increase in plasma levels of cyclosporine and increase the risk of nephrotoxicity. Plasma concentrations of cyclosporine should be regularly monitored.

With the joint appointment of josamycin and digoxin, an increase in the level of the latter in the blood plasma is possible.

Analogues medicinal product Wilprafen

Structural analogues for the active substance:

• Wilprafen Solutab.

Use during pregnancy and lactation

Approved for use during pregnancy and during breastfeeding after medical assessment of benefit or risk.

"Vilprafen 500" is pharmacological drug, which is used in the treatment. It is quite effective, as it contains a broad-spectrum antibiotic. Quite often it is prescribed to those people who are allergic to

"Vilprafen 500": a brief description of and properties

As already mentioned, the drug contains an antibiotic called josamycin, which can affect both gram-positive and gram-negative bacteria. Chlamydia and some mycoplasmas are also sensitive to it.

The active substance of the drug quickly enters the bloodstream - its maximum concentration is reached after an hour after the reception. The antibiotic can accumulate in soft tissues human body, as well as in the skin and lymphatic system. The substance is decomposed by the liver. Outwardly, it is excreted mainly with bile, and only part of it enters the urine.

"Vilprafen" (500 mg): indications for use

The drug is widely used in the treatment of diseases caused by bacterial pathogens. It is prescribed for diseases skin, for example, furunculosis, erysipelas, poidermia.

It is also taken for diseases. respiratory system- bronchitis, laryngitis, scarlet fever, diphtheria, whooping cough, tonsillitis, tonsillitis, pharyngitis, pneumonia (including atypical). In addition, they are treated for dental infections, such as gingivitis or periodontal disease.

"Vilprafen 500" is effective in anthrax, diseases lymph nodes, sinusitis, otitis media, psittacosis, sexually transmitted diseases, infections of the reproductive and urinary systems, prostatitis, gonorrhea. The drug is used by doctors and how aid during the treatment of syphilis. It is simply indispensable for those patients who have developed individual sensitivity to penicillin.

"Vilprafen 500": instructions for use

As a rule, doctors prescribe 1-2 grams of the drug. The frequency of use is approximately two or three times a day. But you can not use the medicine yourself, as it is still an antibiotic. You can take it only as directed by a specialist who will indicate the dosage and mode of administration. The duration of treatment may vary and is determined only by the doctor.

If you forget to take the drug at a certain time of day, then do not use a double dose of the drug at the next dose - return to the normal treatment regimen.

"Vilprafen 500": contraindications and possible side effects

Taking the drug is not possible for those patients who have an individual hypersensitivity to this antibiotic or serious illnesses liver. Very carefully and only with the constant supervision of a doctor, the drug can be used for people with renal insufficiency.

As for side effects, they appear quite rarely. For example, a person may complain of nausea, severe heartburn, loss of appetite, diarrhea, and vomiting. Symptoms of dysbacteriosis may appear, so before you start taking the medicine, you should ask your doctor to prescribe drugs to protect the body from the harmful effects of the antibiotic.

In some cases, when taking the drug "Vilprafen", the outflow of bile may be disturbed, resulting in jaundice.

Cases of the appearance of thrush, urticaria and hearing impairment after taking an antibiotic are considered very rare.

Pregnant women and nursing mothers taking this medication allowed only with the appropriate prescription of a doctor. "Vilprafen 500" interacts differently with other drugs, so if you are taking any other medications, then you should inform your doctor about this.

Antibiotics of the macrolide group are in demand due to their wide spectrum of action and rare side effects. Among them, Wilprafen is very popular. For adults, it is often prescribed for pathologies of the genitourinary organs, peptic ulcer and other bacterial infections. But is it possible to give it to a child, what are the age restrictions on the use of Vilprafen and what do parents say about it?

Release form

The drug is produced in the form of tablets that have a shell. They have an oblong convex shape and a white tint, and there are risks on both sides. One pack of Vilprafen includes one blister with 10 tablets.

There is another form of such a medicine, but since it is presented soluble tablets, such an antibiotic is called Vilprafen Solutab. It is more convenient to give to children, because the tablet can be divided into parts, and before taking it is mixed with water, resulting in a strawberry suspension, which is much easier to swallow than a solid medicine.

Compound

The main ingredient of Vilprafen, thanks to which the drug has antimicrobial action, is josamycin. It is presented in a dose of 500 mg per 1 tablet and is supplemented with substances that help give the drug shape and strength. Among them are methylcellulose, polysorbate 80, talc, MCC, aluminum hydroxide and other compounds.

Operating principle

After entering the digestive tract, the components of the tablet are absorbed very quickly. The maximum concentration of josamycin in the patient's blood is observed within 1 hour after administration. With the bloodstream, the antibiotic penetrates into almost all tissues (except the brain). Especially a lot of medicine gets into the tonsils, saliva, lacrimal fluid and sputum.

In tissues and organs, the drug acts on infectious agents, inhibiting their reproduction and growth. This action, called bacteriostatic, is due to the ability of josamycin to bind to ribosomes inside microbial cells, which interferes with protein synthesis.

Metabolic changes drugs originate in the liver, after which most of the antibiotic is excreted in the bile. Only 1/10 of the total amount of the drug leaves the patient's body with urine.

The spectrum of activity of Vilprafen against bacteria is very extensive. The drug effectively fights different types of strepto- and staphylococci, including such dangerous species for children as pneumococci and Staphylococcus aureus. The drug acts on the causative agent of diphtheria and anthrax, propionobacteria, clostridia, listeria and other gram-positive microorganisms.

Tablets are also active against microbes, which are called gram-negative- gonococci, bordetella, meningococci, Haemophilus influenzae, Legionella, Helicobacter and many others. The drug also acts on intracellular microorganisms, including mycoplasmas, chlamydia and ureaplasma.

Resistance to this drug is very rare. And even if microbes are insensitive to other macrolides, Vilprafen often helps.

Tablets are inactive only against enterobacteria, which is considered their advantage over other antibiotics, since the beneficial intestinal flora is not inhibited as a result of treatment.

Indications

At what age is it allowed to take?

According to the annotation, Vilprafen can be prescribed for children weighing more than 10 kilograms. But given that the drug is available in coated tablets, which are undesirable to break and crumble, the age restrictions on the use of such an antibiotic will be determined by the ability of a small patient to swallow the medication.

Some children can take this form as early as 3 years old, but it is not uncommon for even a 6-7 year old child to have difficulty with hard tablets. In pediatric practice under the age of 4-6 years, they often resort to a soluble form (Vilprafen Solutab). Although such tablets contain more active substance (1000 mg per 1 tablet), they can be divided into halves and quarters, and after mixing with water they form a suspension that can be swallowed by both a child aged 2 years and a one-year-old baby.

Contraindications

Tablets are not prescribed for intolerance to josamycin or any other component. Also, this antibiotic is not prescribed for children with allergies to other macrolides. And due to the fact that the metabolism of the drug occurs mainly in the liver, serious diseases of such an organ are also a contraindication to treatment with Vilprafen.

Side effects

Often children's body tolerates Wilprafen well. If there are side effects, they are often associated with the reaction of the digestive tract and are represented by nausea, discomfort in the stomach, loose stools. Rare side effects tablets are called allergies (urticaria, Quincke's edema and other forms), stomatitis, colitis, jaundice, temporary hearing impairment.

Instructions for use and dosage

• Children weighing more than 10 kg under the age of 14 Vilprafen is prescribed 1 tablet three times a day. The medicine should be taken at regular intervals (every 8 hours).
• Although the annotation states that eating does not affect the absorption of josamycin, doctors recommend drinking the drug 30 minutes before meals. The medication is swallowed and washed down with water.
• For a child over 14 years of age, the drug is prescribed 1-2 tablets twice a day. If required, the daily dosage is increased to 3000 mg and given to the teenager 2 tablets 3 times a day.
• The duration of treatment with Vilprafen can range from 5 days to 3 weeks. It depends on the severity of the disease and is determined individually. At the same time, it is not worth stopping therapy earlier than the period prescribed by the doctor. Even if the condition of a small patient has improved, the course must be completed in order for the treatment to be completed successfully.
• If the pill is missed, you should drink the drug as soon as possible. If the pass was remembered by the time of the next medication, the “forgotten” tablet is not taken in addition to the next one.

In the short video below, Dr. Komarovsky explains how to properly take antibiotics.

Overdose

The manufacturer does not provide any information about the negative effect of an excess dose of josamycin, but doctors suggest that an overdose will be manifested by an increase in side effects from such a drug. First of all, the symptoms will be associated with irritation of the digestive tract. If they appear, you should immediately consult a doctor.

Interaction with other drugs

Vilprafen is incompatible with many other antibacterial drugs, such as clindamycin and drugs with a bactericidal effect. Also, this antibiotic should not be combined with xanthines, digoxin, cyclosporine, ergot alkaloids and antihistamines. Such combinations threaten serious adverse reactions.

Terms of sale

Acquisition of Vilprafen in a pharmacy is possible only upon presentation of a prescription from a doctor. The average price of one pack of medicine is 530 rubles.

Storage conditions and shelf life

You need to keep the tablets at home in a place hidden from the sun's rays, where the drug will not be reached by children. The storage temperature should not exceed +25 degrees. The shelf life of such an antibiotic is 4 years.

Vilprafen: instructions for use and reviews