Vilprafen repeated course. What helps "Vilprafen". Instructions, price and analogues. Vilprafen ® - indications for use

Macrolide antibiotics have a high activity against many infectious agents. One of the representatives of this group antibacterial agents is "Vilprafen Solutab". Is this drug allowed for children, what microorganisms does it affect, how is it used correctly, and what side effects can it provoke?

Release form

The drug is presented as dispersible white-yellow or white oblong tablets. They are sweet in taste, smell like strawberries. On one side of the tablet there is the number 1000, and the other side is marked with the inscription IOSA. The drug is packed in blisters of 5 pieces, and one pack includes 10 tablets.

Compound

The main component of the anbitiotik Vilprafen Solutab is represented by josamycin. Its dosage per tablet is 1000 mg. To make the drug solid, keep its shape and dissolve in water, colloidal silicon dioxide, hyprolose and magnesium stearate are added to it, as well as sodium docusate and microcrystalline cellulose. For a pleasant taste, the preparation contains strawberry flavor and aspartame.

Operating principle

Josamycin has a bacteriostatic effect due to the binding of this substance to the ribosomes of microbial cells, as a result of which the synthesis of protein molecules is disrupted in bacteria. This leads to a slowdown in the reproduction and growth of microorganisms.

The drug is active against:

• Streptococci (including pneumococci and pyogenic species).
• The causative agents of diphtheria.
• meningococci.
• Peptococcus.
• Listeria.
• Staphylococci (including aureus).
• Gonococcus.
• Legionell.
• The causative agents of anthrax.
• Bordetell.
• Clostridia.
• Borelli.
• Pale treponemas.
• Propionobacteria.
• Peptostreptococcus.
• Ureaplasma.
• Moraxell.
• Brucella.
• Gonococcus.
• Helicobacter.
• Hemophilic rods.
• Chlamydia.
• Bacteroids.
• Campylobacter.
• Mycoplasma.

In this case, the drug is often inactive when infected with enterobacteria. It has almost no effect on the normal intestinal microflora. Note also that the drug usually acts on strains of microbes that are resistant to erythromycin and other macrolides.

The tablet is very quickly absorbed in the digestive tract, and food intake does not affect this process in any way. The maximum josamycin in plasma is determined approximately one hour after taking the drug. The half-life of the drug is carried out in 1-2 hours, while only 10% of the drug is excreted by the kidneys, and most of it after metabolic changes excreted in the liver with bile.

Indications

Treatment with the drug "Vilprafen Solutab" is prescribed:

• With tonsillitis, otitis media, paratonsillitis, scarlet fever, tonsillitis, diphtheria, laryngitis and other infections of the upper respiratory tract.
• With bronchitis, whooping cough, community-acquired pneumonia and other bacterial infections of the lower respiratory tract.
• With alveolitis, gingivitis, periodontitis and other dental infections.
• With bacterial lesions of the eyes - for example, with blepharitis.
• With erysipelas, phlegmon, panaritium, furunculosis, burn infection, lymphadenitis and other soft tissue lesions.
• With gonorrhea, chlamydial urethritis, syphilis and other urinary tract infections.
• With diseases of the gastrointestinal tract caused by Helicobacter pylori.

From what age is it applied?

The restriction in the appointment of "Vilprafen Solutab" is not the age of the child, but his weight. The drug is allowed only for children weighing more than 10 kilograms. This means that the drug can be prescribed to one child at 6 months, and tablets can be given to another toddler only from 1 year. It all depends on body weight.

Contraindications

"Vilprafen Solutab" is not prescribed if the child has:

• There is an intolerance to josamycin or other ingredients of the tablets.
• An allergy to any macrolide antibiotic was found.
• The work of the liver is severely impaired.

Side effects

Children's body may react to "Vilprafen Solutab" with the appearance of:

• Nausea.
• Discomfort in the stomach.
• Vomiting.
• Liquefaction of the stool.

Rare side effects from taking such an antibiotic: constipation, Quincke's edema, decreased appetite, stomatitis, urticaria, jaundice, hearing impairment or purpura.

Instructions for use and dosage

• "Vilprafen Solutab" can be taken different ways- how to swallow a tablet or part of it with water, and dissolve the drug in water, taking a liquid in a volume of 20 ml or more. If the drug dissolves, the suspension must be mixed well before swallowing.
• The daily dose of "Vilprafen Solutab" for a child is calculated by weight. For 1 kilogram of body weight, you need from 40 to 50 mg of the active substance. For example, a 4-year-old child weighing 16 kg will receive 750 mg of josamycin per day, so he is given 1/4 tablet three times a day. If the baby is 6 years old, and his weight is 20 kg, then the daily dose will be 50x20 = 1000 mg. This amount corresponds to 1 tablet. For such a small patient, the medication is prescribed 1/2 tablet twice a day.
• At the age of over 14 years, 1-2 pieces per day are prescribed, dividing this dosage into 2 or 3 doses. If required, the dose can be increased up to 3 tablets per day.
• How long to drink the drug - in each case, the doctor determines individually. The duration of taking an antibiotic can be either 5 days or 3 weeks. For example, with streptococcal angina, Wilprafen Solutab is prescribed for at least 10 days.

Overdose

So far, there have been no cases of overdose, but doctors suggest that exceeding the dose of soluble tablets will lead to backlash digestive tract (in the form of vomiting, stomach discomfort or diarrhea). In case of problems, you should consult a doctor.

Interaction with other drugs

• "Vilprafen Solutab" is not prescribed together with any bactericidal antibiotics, as well as with representatives of the lincosamide group.
• If you take antihistamines (astemizole or terfenadine drugs) at the same time, the risk of heart rhythm disturbances increases.
• It is not advised to combine treatment with josamycin and xanthines, cyclosporine or ergot alkaloids.

Terms of sale

Buying "Vilprafen Solutab" requires a prescription from a doctor. The average cost of one package of medicine is 650 rubles.

Storage features

To store the drug, you should find a place where the drug cannot be reached. Small child. The temperature during storage of the medicine should not exceed 25 degrees Celsius. The shelf life of dispersible tablets is 2 years.

Start of application antimicrobials for the treatment of diseases of an inflammatory or infectious nature, they date back to 1928 and are associated with the name of A. Fleming, who discovered the antibiotic penicillin. And then, in less than 100 years, hundreds of different antibacterial drugs were created, the effect of which is detrimental to pathogens.

All antibiotics according to the therapeutic effect of exposure to pathogenic microorganisms are divided into medicines. bactericidal and bacteriostatic.

Preparations of the first group cause bacteria to die, second - prevent them from multiplying. Currently, the safest (they can be taken by pregnant women) are antibiotics - macrolides. This group includes drugs of complex chemical structure, which have a bacteriostatic effect on microorganisms.

An example is that which is used in the treatment of many infectious diseases and inflammations.

The effect of the drug is especially effective in the treatment of bacterial infections, when it becomes necessary to replace penicillin drugs.

Composition of Wilprafen Solutab

The active ingredient in the antibiotic Josamycin It has an effect at the level of the intracellular structure of bacteria and affects their vital activity, disrupting the synthesis processes in the cells of microorganisms.

The composition of 1 tablet of Vilprafen Solutab contains Josamycin - 1000 mg, which is equivalent to josamycin propionate in the amount of 1067.66 mg.

This dosage form The drug is represented by tablets (soluble) of white color with a yellowish tint, the taste is sweet, with a pleasant strawberry smell. On one side, the inscription joza is applied to their surface, and on the other side, “1000”.

as ancillary components in antibiotic composition includes:

• microcrystalline cellulose - 564.53 mg;
• hyproloses - 199.82 mg;
• docusate sodium - 10.02 mg;
• aspartame - 10.09 mg;
• colloidal silicon dioxide - 2.91 mg;
• flavoring (strawberry) - 50.05 mg;
• magnesium stearate - 34.92 mg.

Indications for use Vilprafen Solutab

Application remedy from the group of antibiotics, it is advisable only against microorganisms sensitive to the action of the active substance of the drug. In the case of Vilprafen Solutab, its active ingredient, josamycin, effectively fights the following types of bacteria:

• gram-positive: streptococci, corynbacteria, mycoplasma, staphylococci, legionella, peptococci, peptostreptococci, Propionibacterium acnes, Bacillus anthracis, clostridium spp;
• intracellular bacteria: mycoplasma, ureaplasma, treponema, chlamydia;
• meningococci, gonococci, hemophilic bacteria, as well as the Helicobacter type.

The drug is not active against enterobacteria, therefore, the effect on the microflora and gastric mucosa and intestinal tract characterized as weak. At the same time, it should be noted the effectiveness of Vilprafen Solutab with simultaneous resistance of the patient's body to erythromycins and drugs of the macrolide group. In contrast, resistance to josamycin in patients is rare.

Indications for the use of antibiotics are:

The drug is characterized by rapid absorption and a good level of membrane penetration. Therefore, in order to achieve a stable concentration, the antibiotic must be taken with a break of 12 hours. After 48-96 hours of regular medication, the amount in the blood will be stable.

Max level active ingredient fixed after 1 hour after application. From the body, josamycin is excreted to a greater extent with bile, less - with urine.

Instructions for use Vilprafen Solutab 1000, drug price

The procedure for treatment and other useful information about Vilprafen Solutab 1000 instructions for use (the price of the drug for 10 pieces from 711 rubles) describes accurately and clearly. Therefore, before a patient - an adult or a child begins to take an antibiotic, you should carefully read the instructions for the dosing regimen, precautions, drug interaction as well as the side effects of the tablets.

How to take Wilprafen Solutab

For an adult and a child (over 14 years old), the instructions prescribe the use of an antibiotic in a daily dose of 1-2 mg in two or three doses. Preferably between meals.

For example, if, as prescribed by a doctor, you need to take 1 mg of the drug per day, then for this one tablet of vilprafen solutab 1000 mg is dissolved in a glass of water and the medicine is drunk. Duration of treatment - from 5 days to 3 weeks.

In the case of therapy for an infectious streptococcal disease, the duration of the course according to the instructions is 10 days.

And also the instructions describe the duration of treatment with Vilprafen Solutab how to take it for the following diseases:

• antihelicobacter therapy. The course is 7–14 days. Combined treatment, with dosed use of combined drugs;
• urogenital chlamydia. Course from twelve to fourteen days;
• rosacea. The duration of the course is ten or fifteen days;
• ureaplasma, chlamydia. Tablets of 1000 mg are taken 2 times a day (as part of complex therapy).

The duration of the course of antibiotic use in all cases is determined by the doctor.

Side effects of Wilprafen Solutab

The instructions contain a list of side effects that may occur during treatment:

1. Gastrointestinal disorders: nausea, loss of appetite, heartburn. Possible diarrhea, dysbacteriosis, candidiasis;
2. Biliary tract and liver: increased levels of liver enzymes (in blood plasma). Rarely - a violation of the outflow of bile, jaundice.
3. Allergic reactions: urticaria, skin rash.
4. Hearing impairment. A condition that is often dose-related. After correction of the dosing regimen, the patient's hearing returns to normal.

And also in the instructions it is noted that an overdose of an antibiotic can lead to side effects of tablets in the form of various disorders of the gastrointestinal tract. In such cases, the patient is recommended to reduce the dosage of the drug.

Important: medicine contraindicated for use in patients with hypersensitivity to the substances that make up its composition.

Given the presence of Wilprafen Solutab side effects, an antibiotic is prescribed with caution in therapy for pregnant women and mothers who are breastfeeding. Also, patients with kidney failure. Such patients need to undergo special laboratory tests in order to make a decision on the appointment of a medication based on their results.

Instructions for use Vilprafen Solutab for children

Before starting treatment, the child's parents receive advice from the doctor regarding the correct use of the antibiotic. In addition, they should familiarize themselves with the part of the instructions where the features of the treatment of children with Vilprafen Solutab are prescribed.

For different age categories, the manufacturer produces this medication in solid or liquid form:

• tablets of white color, oblong shape, containing 500 mg of josamycin;
• Vilprafen Solutab tablets (content active substance– 1000 mg). They dissolve in water, sweet in taste, fragrant;
• suspension. Each 10 ml liquid preparation contains josamycin 300 mg. As well as excipients: magnesium stearate, microcrystalline cellulose, aluminum hydroxide, titanium dioxide, anhydrous colloidal silica.

1. Indications for use for children.

The drug can be prescribed to a child if he is diagnosed with infectious diseases:

• throat, ear, nose, or lesions upper division respiratory system: tonsillitis, pharyngitis, tonsillitis, laryngitis, sinusitis, inflammation of the middle ear;
• lower respiratory tract: bronchitis (acute), bronchopneumonia, pneumonia, whooping cough;
• skin or soft tissues: phlegmon, furunculosis, lymphadenitis, phlegmon, pyoderma, erysipelas;
• genitourinary system in the form of: ureaplasma, urethritis, chlamydia, pyelonephritis, mycoplasmosis, epididymitis;
• oral cavity: gingivitis, stomatitis, periodontal disease.

And also Vilprafen, an antibiotic that effectively replaces penicillin in the treatment of diphtheria, scarlet fever, is prescribed if a child has hypersensitivity to penicillin group drugs.

1. Method of application, doses.

According to the instructions, the dosage regimen of the drug is determined based on the exact weight of the child:

• for body weight, not more than 10 kg, a dose of 40-50 mg / kg should be divided into 2 or 3 doses;
• for body weight from 10 to 20 kg 1/2 or 1/4 tablets are dissolved in water. The medicine is given to drink to the child 2 r. in a day;
• children weighing 20 to 40 kg should take one or half tablets (500 mg or 1000 mg), respectively, 2 r. per day;
• for a child whose weight is more than 40 kg, appoint 1 tablet (whole) 2 r. per day.

For infants and young children, you can purchase a suspension of Vilprafen. It is recommended to give 3 r. per day. The dose of the drug can be calculated based on the body weight of the child:

• starting from 3 to 12 months (body weight 5.5-10 kg), you need to give medicine, measuring from 2.5 to 5 ml;
• from one to six years (body weight 10-21 kg) recommended doses of suspension for treatment - 5-10 ml each;
• from six to fourteen years old with a body weight of 21 kg - the dose is 10-15 ml.

The drug is poured into a measuring cup and given to the child to drink between meals.

1. Side effects.

Vilprafen solutab can cause adverse reactions in the form of nausea, diarrhea, discomfort from the gastrointestinal tract, liver, and also provoke the appearance of urticaria or swelling. Very rare purpura and hearing loss.

Any of these manifestations should be immediately reported to the doctor in order to adjust the treatment regimen for the child.

Conclusion

In most of the reviews of patients who were prescribed the antibiotic Vilprafen Solutab 1000 for treatment, the high efficiency of its therapeutic effect was noted. At the same time, for a complete recovery, the patient must strictly follow all the doctor's recommendations for the use of the drug and follow the instructions set out in the instructions.

The macrolide antibiotic is Vilprafen. Instructions for use indicate that 500 mg and 1000 mg tablets of Solutab have bactericidal and bacteriostatic properties. According to doctors, this drug helps in the treatment of ureaplasmosis, chlamydia, bronchitis, pneumonia and other infections.

Release form and composition

The drug is produced in the form of coated tablets. The blister pack contains 10 such tablets. The packaging is enclosed in a cardboard box.

Also, the drug is available in the form of a suspension. It is contained in dark glass bottles, 100 ml per bottle. The kit includes a measuring cup.

The composition of Vilprafen is as follows:

• one tablet contains 500 mg of josamycin or 1000 mg (Vilprafen Solutab);
• suspension (10 ml) contains 300 mg of josamycin.

Indications for use

What helps Vilprafen (Solutab)? Tablets are prescribed:

• People with hypersensitivity to penicillin in scarlet fever.
• Infectious diseases that cause inflammatory processes that were caused by microorganisms with high sensitivity to the drug.
• infections skin and soft tissues (with boils, pyoderma, lymphadenitis, etc.)
• It is used in the treatment of diphtheria in addition to therapy with diphtheria antitoxin.
• Infections of the oral cavity (for periodontal disease, gingivitis).
• Infectious diseases of the upper respiratory tract and upper respiratory tract (used for tonsillitis, pharyngitis, tonsillitis, sinusitis, laryngitis, otitis media).
• lower respiratory infections (pneumonia, acute bronchitis whooping cough, bronchopneumonia).
• Infections of the genitourinary organs (with chlamydia, with ureaplasma, gonorrhea, urethritis, prostatitis, etc.)

Instructions for use

Vilprafen is taken in the recommended daily dose for adults and adolescents over the age of 14, which is 1-2 g, in 2-3 doses. If necessary, the dose can be increased to 3 g per day. Children aged 1 year have an average body weight of 10 kg.

The daily dose for children weighing at least 10 kg is prescribed on the basis of 40-50 mg / kg of body weight daily, divided into 2-3 doses:

• children weighing 10-20 kg are prescribed 250-500 mg (1/4-1/2 tablets dissolved in water) 2 times a day;
• children weighing 20-40 kg are prescribed 500-1000 mg (1/2-1 tablet dissolved in water) 2 times a day;
• children weighing over 40 kg - 1000 mg (1 tablet) 2 times a day.

Usually the duration of treatment is determined by the doctor and ranges from 5 to 21 days, depending on the nature and severity of the infection. In accordance with WHO recommendations, the duration of treatment for streptococcal tonsillitis should be at least 10 days.

In anti-Helicobacter therapy regimens, Vilprafen is prescribed at a dose of 1 g 2 times a day for 7-14 days in combination with other drugs in their standard doses:

• famotidine 40 mg daily or ranitidine 150 mg twice daily + josamycin 1 g twice daily + metronidazole 500 mg twice daily;
• omeprazole 20 mg (or lansoprazole 30 mg, or pantoprazole 40 mg, or esomeprazole 20 mg, or rabeprazole 20 mg) twice daily + amoxicillin 1 g twice daily + josamycin 1 g twice daily;
• omeprazole 20 mg (or lansoprazole 30 mg or pantoprazole 40 mg or esomeprazole 20 mg or rabeprazole 20 mg) twice daily + amoxicillin 1 g twice daily + josamycin 1 g twice daily + bismuth tripotassium dicitrate 240 mg 2 times a day;
• famotidine 40 mg daily + furazolidone 100 mg twice daily + josamycin 1 g twice daily + bismuth tripotassium dicitrate 240 mg twice daily).

In the presence of atrophy of the gastric mucosa with achlorhydria, confirmed by pH-metry: amoxicillin 1 g 2 times a day + josamycin 1 g 2 times a day + bismuth tripotassium dicitrate 240 mg 2 times a day.

The instruction to Vilprafen Solutab provides that the drug can be taken in different ways: you can take the tablet with water, or before dissolving in 20 ml of water. The suspension that formed after the dissolution of the tablet must be mixed very carefully.

Vilprafen tablets should be swallowed whole. Often patients are interested in how to take, before or after meals. The instructions indicate that the tablets must be swallowed between main meals.

When treating, it should be borne in mind that if one dose is missed, you must immediately take a dose of the drug. However, if it is time for the next dose, you should not take the missed dose, you should return to the usual treatment regimen. Do not double dose. Interruption in treatment or premature discontinuation of the drug reduces the likelihood of success of therapy.

pharmachologic effect

The drug is an antibiotic that belongs to the group of macroliths. The bacteriostatic effect of the drug is due to the inhibition of protein synthesis by bacteria. If there are foci of inflammation, the drug has a bactericidal effect.

Vilprafen is highly effective against such intracellular microorganisms as Mycoplasma pneumoniae, Ureaplasma urealyticum, Chlamydia trachomatis, Legionella pneumophila, Chlamydia pneumonuae, Mycoplasma hominis.

High activity is also observed against gram-negative aerobic bacteria:

• Haemophilus influenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Bordetella pertussis;
• gram-positive aerobic bacteria: Streptococcus pyogenes, Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus pneumoniae;
• anaerobic bacteria: Peptostreptococcus, Peptococcus, Clostridium perfringens.

The drug is effective against Treponema pallidum. The active substance of the drug is josamycin, which is completely and rapidly absorbed from the gastrointestinal tract.

Contraindications

Vilprafen is contraindicated in patients with the following conditions:

• Liver failure.
• Individual intolerance to the constituent components of the drug.
• Past severe allergic reactions to drugs from the macrolide group.
• Pregnancy and the period of breastfeeding.

Side effects

While taking Vilprafen, development of disorders from the side is possible. various systems body:

• In severe persistent diarrhea, the possibility of developing pseudomembranous colitis (which is life-threatening) due to the action of an antibiotic should be borne in mind.
• Hypersensitivity reactions: in some cases - allergic skin reactions (eg, urticaria).
• Gastrointestinal tract: rarely - heartburn, nausea, loss of appetite, diarrhea and vomiting.
• Hearing aid: in rare cases, dose-dependent transient hearing loss.
• Biliary tract and liver: in some cases - a transient increase in the activity of liver enzymes in the blood plasma, sometimes accompanied by jaundice and a violation of the outflow of bile.

Children, during pregnancy and lactation

The drug is not prescribed for pregnant women if there are severe disorders in the liver, sensitivity to the constituent components.

In childhood

The drug is not prescribed to premature babies. Newborn patients with impaired liver function are treated under strict supervision.

Vilprafen for children under the age of 14 is used as a suspension.

Vilprafen 1000 mg Solutab can be dissolved in water to prepare a suspension. If treatment with the drug is prescribed for children, the dosage is as follows: 30-50 mg per 1 kg of body weight is divided into three doses.

Suspension for children up to three months of age is dosed according to the exact weight of the child. Why tablets are used, and whether they should be used for treatment, should be checked with a doctor.

special instructions

With the simultaneous appointment of Vilprafen with ergot alkaloids, vasoconstriction may increase. Therefore, in this case, careful monitoring of the patient's condition is necessary.

Simultaneous administration of josamycin and cyclosporine provokes an increase in the level of cyclosporine in the blood plasma. Also in the blood there is a nephrotoxic concentration of cyclosporine. With such treatment, it is necessary to ensure constant monitoring of plasma concentrations of cyclosporine.

drug interaction

If Vilprafen is prescribed simultaneously with antihistamines containing terfenadine or astemizole, the process of excretion of these substances sometimes slows down, which ultimately leads to the manifestation of life-threatening cardiac arrhythmias.

If you take Vilprafen and Digoxin at the same time, the level of digoxin in the blood plasma may increase.

Speaking about the interaction with other drugs, it should be borne in mind that Vilprafen is an antibiotic. Before using any drug, it is imperative to determine whether it is an antibiotic or not.

When taken with hormonal contraceptives may reduce the effect of the latter. In such a situation, it is recommended to use additional hormonal contraceptives.

With the development of pseudomembranous colitis, Vilprafen should be discontinued and appropriate treatment prescribed. It is contraindicated to take drugs that reduce intestinal motility. Patients with renal insufficiency need to adjust the dosing regimen in accordance with the values ​​of creatinine clearance (CC).

According to the instructions, Vilprafen is not prescribed to premature babies. When used in newborns, liver function should be monitored. It is necessary to take into account the possibility of cross-resistance to various antibiotic drugs of the macrolide group.

Vilprafen's analogs

According to the structure, analogues are determined:

1. Wilprafen Solutab.
2. Josamycin.

Analogues that belong to the group of macrolides have a similar effect:

1. Roxithromycin.
2. Spiramycin.

Often patients are interested in how Vilprafen differs from Vilprafen Solutab. What is the difference between these drugs, due to their form of release.

Vilprafen is a conventional film-coated tablet. Solutab is soluble tablets which have a sweet taste and fruity aroma. They can be taken both in the form of tablets and in the form of a suspension.

Registration number:

Tradename: VILPRAFEN SOLUTAB

international generic name(INN): Josamycin

Dosage form: dispersible tablets

Composition per 1 tablet

Active substance:
Josamycin - 1000 mg (which is equivalent to josamycin propionate) - 1067.66 mg.

Excipients:
Microcrystalline cellulose - 564.53 mg, hyprolose - 199.82 mg, docusate sodium - 10.02 mg, aspartame - 10.09 mg, colloidal silicon dioxide - 2.91 mg, strawberry flavor - 50.05 mg, magnesium stearate - 34.92 mg.

Description:

White or white with a yellowish tint, oblong-shaped tablets, sweet, with a strawberry smell. With the inscription "JOSA" and a notch on one side of the tablet and the inscription "1000" on the other.

Pharmacotherapeutic group: antibiotic, macrolide.

ATC code: J01FA07

Pharmacological properties

Pharmacodynamics.
The drug is used to treat bacterial infections; The bacteriostatic activity of josamycin, like other macrolides, is due to the inhibition of bacterial protein synthesis. When creating high concentrations in the focus of inflammation, it has a bactericidal effect.
Josamycin is highly active against intracellular microorganisms (Chlamydia trachomatis and Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Legionella pneumophila); gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae (pneumococcus), Corynebacterium diphteriae), gram-negative bacteria (Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis), and also against some anaerobic bacteria (Peptococcus, Peptostreptococcus, Clostridium perfringium). Slightly affects enterobacteria, therefore, little changes the natural bacterial flora of the gastrointestinal tract. Effective with resistance to erythromycin. Resistance to josamycin develops less frequently than to other macrolide antibiotics.

Pharmacokinetics.
After oral administration, josamycin is rapidly and completely absorbed from the gastrointestinal tract, food intake does not affect bioavailability. The maximum concentration of josamycin in serum is reached 1-2 hours after administration. About 15% of josamycin binds to plasma proteins. Particularly high concentrations of the substance are found in the lungs, tonsils, saliva, sweat and lacrimal fluid. The concentration in sputum exceeds the concentration in plasma by 8-9 times. accumulates in bone tissue. Passes the placental barrier, is secreted into breast milk. Josamycin is metabolized in the liver to less active metabolites and excreted mainly in the bile. Urinary excretion of the drug is less than 20%.

Indications for use

Acute and chronic infections caused by susceptible organisms, such as:
Infections of the upper respiratory tract and ENT organs:
Angina, pharyngitis, paratonsillitis, laryngitis, otitis media, sinusitis, diphtheria (in addition to treatment with diphtheria toxoid), as well as scarlet fever in case of hypersensitivity to penicillin.
Lower respiratory tract infections:
Acute bronchitis, exacerbation of chronic bronchitis, pneumonia (including those caused by atypical pathogens), whooping cough, psittacosis.
dental infections
Gingivitis and periodontal disease. Infections in ophthalmology Blepharitis, dacryocystitis.
Skin and soft tissue infections
Pyoderma, furunculosis, anthrax, erysipelas (with increased sensitivity to penicillin), acne, lymphangitis, lymphadenitis, lymphogranuloma venereum.
Urinary tract infections
Prostatitis, urethritis, gonorrhea, syphilis (with hypersensitivity to penicillin), chlamydia, mycoplasma (including ureaplasma) and mixed infections.

Contraindications

hypersensitivity to macrolide antibiotics severe liver dysfunction

Pregnancy and lactation

Approved for use during pregnancy and during breastfeeding after medical benefit/risk evaluation. The WHO European Office recommends josamycin as the drug of choice for the treatment of chlamydial infection in pregnant women.

Dosage and administration

The recommended daily dosage for adults and adolescents over 14 years of age is 1 to 2 g of josamycin. The daily dose should be divided into 2-3 doses. If necessary, the dose can be increased to 3 g per day.
Children aged 1 year have an average body weight of 10 kg.
The daily dosage for children weighing at least 10 kg is prescribed based on the calculation of 40-50 mg / kg body weight daily, divided into 2-3 doses: for children weighing 10-20 kg, the drug is prescribed 250-500 mg ( 1/4-1/2 tablets dissolved in water) 2 times a day, for children weighing 20-40 kg, the drug is prescribed 500 mg-1000 mg (1/2 tablet -1 tablet dissolved in water) 2 times per day, more than 40 kg - 1000 mg (1 tablet) 2 times a day.
Usually the duration of treatment is determined by the doctor. In accordance with the recommendations of the World Health Organization on the use of antibiotics, the duration of treatment for streptococcal infections should be at least 10 days.

In anti-Helicobacter therapy regimens, josamycin is prescribed at a dose of 1 g 2 times a day for 7-14 days in combination with other drugs in their standard dosages (famotidine 40 mg / day or ranitidine 150 mg 2 r / day + josamycin 1 g 2 r / day day + metronidazole 500 mg twice daily; omeprazole 20 mg (or lansoprazole 30 mg or pantoprazole 40 mg or esomeprazole 20 mg or rabeprazole 20 mg) twice daily + amoxicillin 1 g twice daily + josamycin 1 g 2 r/day; omeprazole 20 mg (or lansoprazole 30 mg, or pantoprazole 40 mg, or esomeprazole 20 mg, or rabeprazole 20 mg) bid + amoxicillin 1 g bid + josamycin 1 g bid + bismuth tripotassium dicitrate 240 mg 2 r/day: famotidine 40 mg/day + furazolidone 100 mg 2 r/day + josamycin 1 g 2 r/day + bismuth tripotassium dicitrate 240 mg 2 r/day).

In the presence of atrophy of the gastric mucosa with achlorhydria, confirmed by pH-metry: Amoxicillin 1 g 2 r / day + josamycin 1 g 2 r / day + tripotassium bismuth d and citrate 240 mg 2 r / day.

In the case of acne vulgaris and globulus, it is recommended to prescribe josamycin at a dose of 500 mg twice a day for the first 2-4 weeks, then 500 mg of josamycin once a day as maintenance treatment for 8 weeks.

Dispersible tablets Vilprafen Solutab can be taken in various ways: the tablet can be swallowed whole with water or previously, before taking, dissolved in water. Tablets should be dissolved in at least 20 ml of water. Before taking, mix the resulting suspension thoroughly.

Impact on ability to drive vehicles and work with mechanisms
There was no effect of the drug on the ability to drive vehicles and work with mechanisms.

Side effect

From the gastrointestinal tract
Rarely - loss of appetite, nausea, heartburn, vomiting, dysbacteriosis and diarrhea. In the case of persistent severe diarrhea, one should keep in mind the possibility of developing life-threatening pseudomembranous colitis against the background of antibiotics.
Hypersensitivity reactions:
In extremely rare cases, allergic skin reactions (eg, urticaria) are possible.
From the side of the liver and biliary tract
In some cases, a transient increase in the activity of liver enzymes in the blood plasma was observed, in rare cases accompanied by a violation of the outflow of bile and jaundice.
From the side of the hearing aid
In rare cases, dose-dependent transient hearing loss has been reported.
Others: very rarely - candidiasis.

Overdose and other mistakes when taking

To date, there are no data on specific symptoms of poisoning. In case of overdose, the occurrence of the symptoms described in the section " Side effects”, especially from the gastrointestinal tract. If one dose is missed, you must immediately take a dose of the drug. However, if it is time for the next dose, do not take the "forgotten" dose, but return to the usual treatment regimen. Do not double the dose. Interruption in treatment or premature discontinuation of the drug reduces the likelihood of treatment success.

Interaction with other drugs

Vilprafen Solutab / other antibiotics
Since bacteriostatic antibiotics may reduce the bactericidal effect of other antibiotics such as penicillins and cephalosporins, co-administration of josamycin with these types of antibiotics should be avoided. Josamycin should not be co-administered with lincomycin, as there may be a mutual decrease in their effectiveness.
Vilprafen Solutab / xanthines
Some representatives of macrolide antibiotics slow down the elimination of xanthines (theophylline), which can lead to possible intoxication. Clinical and experimental studies indicate that josamycin has less effect on theophylline release than other macrolide antibiotics.
Vilprafen Solutab / antihistamines
After the joint appointment of josamycin and antihistamines containing terfenadine or astemizole, there may be a slowdown in the excretion of terfenadine and astemizole, which in turn can lead to the development of life-threatening cardiac arrhythmias.
Vilprafen Solutab / ergot alkaloids
There are individual reports of increased vasoconstriction after the co-administration of ergot alkaloids and macrolide antibiotics. There has been one case of ergotamine intolerance in a patient while taking josamycin. Therefore, the concomitant use of josamycin and ergotamine should be accompanied by appropriate monitoring of patients.
Vilprafen Solutab / cyclosporine
Co-administration of josamycin and cyclosporine can cause an increase in the level of cyclosporine in the blood plasma and the creation of a nephrotoxic concentration of cyclosporine in the blood. Plasma concentrations of cyclosporine should be regularly monitored.
Vilprafen Solutab / digoxin
With the joint appointment of josamycin and digoxin, an increase in the level of the latter in the blood plasma is possible.
Vilprafen Solutab / hormonal contraceptives
In rare cases contraceptive effect hormonal contraceptives may be insufficient during treatment with macrolides. In this case, it is recommended to additionally use non-hormonal agents contraception.

special instructions

In patients with renal insufficiency, treatment should be based on the results of appropriate laboratory tests.
Consideration should be given to the possibility of cross-resistance to various macrolide antibiotics (eg, organisms resistant to treatment with chemically related antibiotics may also be resistant to josamycin).

Release form: 1000 mg dispersible tablets.
Standard Packing:
5 or 6 dispersible tablets in a blister made of PVC film and aluminum foil. 2 blisters with instructions for use in a cardboard box.

Shelf life: 2 years

Vilprafen Solutab should not be used after the expiry date which is stated on the package.

Storage conditions

List B.
Store in a dry, dark place at a temperature not exceeding 25°C.
Keep the medicine out of the reach of children!

Terms of dispensing from pharmacies

Released by prescription

Registration applicant (registration holder)

Astsllas Pharma Europe B.V., Elizabethof 19, 2353 EB Leiderdorp,
Netherlands / Astellas Pharma Europe B.V.,
Elisabethhof 19.2353 EW Leiderdorp, The Netherlands.

Manufacturer:
Montefarmaco S.
Italy/Montefarmaco S.p.A.
Via Galilei, n.7, 20016 Pero (MI), Italy

Packer (primary packaging)
Montefarmaco S.p.A., Italy

Packer (secondary/tertiary packaging)
Montefarmaco S.p.A., Italy or Temmler Italia S.rL., Italy
Issuing quality control
Temmler Italia S.r.L., Italy
Subject to packaging at ORTAT CJSC
Manufacturer Montefarmaco S.
Italy/Montefarmaco S.p.A. Via Galilei, n.7,20016 Pero (MG), Italia

Packer and release control
ZAO ORTAT, Russia
157092, Kostroma region, Susaninsky
district, s. Northern, m-n Kharitonovo.

Claims should be sent to the Moscow Representative Office of Astellas
Pharma Yuroy B.V. by the address:
109147 Moscow, Marksistskaya st. sixteen,
"Mosalarko Plaza-1" business center,

The site provides background information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Antibiotic Vilprafen

In therapeutic doses, the drug acts bacteriostatically on pathogens (depresses their vital activity), and at high concentrations, its effect becomes bactericidal (detrimental to bacteria).

The drug is effective against many microorganisms - gram-negative (meningococci, gonococci, Haemophilus influenzae, Helicobacter pylori, etc.) and gram-positive (staphylococci, streptococci, pneumococci, corynebacterium diphtheria, etc.). It is also prescribed to fight intracellular microorganisms (chlamydia, mycoplasma, ureaplasma, etc.), as well as some anaerobic bacteria (peptococci, peptostreptococci, bacteroids and clostridia).

Vilprafen is rapidly absorbed from the digestive tract. Within an hour, its maximum concentration in the blood is reached. At the same time, Vilprafen has a long-term therapeutic effect.

The drug crosses the placental barrier and can be excreted in breast milk.

The drug is inactive against enterobacteria, therefore, it practically does not affect the intestinal microflora.

80% of Vilprafen is excreted in the bile, 20% in the urine.

Release form

Vilprafen is available in tablets and in suspension:

• White, oblong, film-coated tablets containing 500 mg of the active substance josamycin. In a carton box there is a blister of 10 tablets.
• Dispersible (quick-acting, soluble) tablets Vilprafen Solutab have a sweet taste and smell of strawberries. They contain 1000 mg of the active ingredient josamycin. The package contains two blisters with 5 or 6 tablets.
• Vilprafen suspension contains 300 mg of josamycin per 10 ml. Packaged in dark glass bottles of 100 ml.

Application instruction of Vilprafen

Indications for use

• pharyngitis (inflammation of the throat);
• laryngitis (inflammation of the larynx);
• otitis media (inflammation of the middle ear);
• paratonsillitis;
• diphtheria (in complex treatment together with diphtheria toxoid);
• scarlet fever (if the patient has an increased sensitivity to penicillin preparations).

• acute bronchitis;
• exacerbation of chronic bronchitis;
• pneumonia;
• bronchopneumonia;
• psittacosis (ornithosis - infection transmitted to humans from sick birds).

Mouth infections (dental):

• stomatitis;
• gingivitis (inflammation of the gums);
• pericoronitis (inflammation of the gums around the molars);
• alveolitis (inflammation of the hole after tooth extraction);
• alveolar abscess.

• blepharitis (inflammation of the eyelids);
• dacryocystitis (inflammation of the lacrimal sac due to impaired patency of the nasolacrimal duct).

• pyoderma;
• venereal lymphogranuloma;
• lymphadenitis (inflammation of the lymph nodes);
• lymphangitis (inflammation of the lymphatic vessels);
• felon (purulent inflammation of the fingers or toes);
• abscess;
• erysipelas
• wound infections that arose as a result of injuries, burns and surgeries.

• syphilis (if the patient has hypersensitivity to penicillin preparations);
• chlamydia;
• mycoplasmosis;
• ureaplasmosis;
• cystitis;
• epididymitis (inflammation of the epididymis).

Contraindications

• Hypersensitivity to the active substance - josamycin, or auxiliary components of the drug;
• allergy to taking other antibiotics from the macrolide group;
• liver diseases, leading to a severe violation of its functions or to disruption of the bile ducts;
• prematurity of children.

Side effects

• decrease or complete loss of appetite;
• discomfort in the stomach or abdomen;
• nausea;
• vomit;
• stool disorders - diarrhea or constipation;
• pseudomembranous colitis (as a result of prolonged diarrhea).

• transient (sudden and transient) increase in the activity of liver enzymes in the blood;
• violation of the outflow of bile;

• erythema multiforme exudative and malignant erythema (Stevens-Johnson syndrome);
• anaphylactoid reaction;
• bullous dermatitis ( allergic reaction in which large fluid-filled blisters appear on the skin);

• transient hearing loss;
• purpura (small capillary hemorrhages in the skin).

Treatment with Vilprafen

Tablets Vilprafen Solutab can be swallowed whole or diluted in 20 ml of water, mix and drink the resulting suspension.

If the patient forgot to take the next dose, then you should do it immediately, but in no case should you take a double dose (together with the "forgotten").

Dosage of Vilprafen
The dosage and course of treatment depend on the diagnosis. Vilprafen can only be prescribed by a doctor.

Usually therapeutic daily dose the drug for children over 14 years of age and adults is 1-2 g and must be divided into 2-3 doses (500 mg each). In severe cases, the dose of Vilprafen can be increased to 3 g per day.

The initial dose of the drug is 1 g.

The course of treatment can be 5 - 21 days; its duration depends on the severity of the inflammatory process.

The duration of the treatment course is at least 10 days.

During treatment, you need to refrain from sexual activity. Give up alcohol, smoking, salty, spicy and spicy foods.

Treatment is prescribed in courses, each of which lasts 7 to 10 days. In each subsequent course, Vilprafen is continued, and the second antibiotic is changed.

The total duration of treatment is determined by the doctor based on the results of control tests.

Vilprafen and alcohol

With the joint intake of alcohol and Vilprafen, digestive tract disorders are possible, which manifest themselves as nausea, vomiting, diarrhea and abdominal pain.

Also, the reaction may be delayed and manifest itself over time in the form of cirrhosis of the liver due to the toxic effects of Wilprafen and alcohol on the liver.

Vilprafen's analogs

• Midecamycin;
• Spiramycin;